Renal failure is a major health problem that is increasing worldwide. To improve clinical
outcomes, we need to understand the basic mechanisms of kidney disease. Aging is a risk …

Sirtuins (SIRTs) are class III histone deacetylases (HDACs) that play important roles in aging
and a wide range of cellular functions. Sirtuins are crucial to numerous biological processes …

Poor control of metabolic diseases induces kidney injury, resulting in microalbuminuria,
renal insufficiency and, ultimately, chronic kidney disease. The potential pathogenetic …

Sirtuins belong to an evolutionarily conserved family of NAD+-dependent deacetylases that
share multiple cellular functions related to proliferation, DNA repair, mitochondrial energy …

Sirtuins, which are NAD+-dependent class III histone deacetylases, are involved in various
biological processes, including DNA damage repair, immune inflammation, oxidative stress …

Sirtuins are members of the Sir2 (silent information regulator 2) family, a group of class III
deacetylases. Mammals have seven different sirtuins, SIRT1–SIRT7. Among them, SIRT1 …

Sirtuins (silent information regulator 2 [Sir2] proteins) belong to an ancient family of
evolutionary conserved nicotinamide adenine dinucleotide (NAD)+-dependent enzymes …

Abstract Sirtuin 1 (SIRT1) is an evolutionary conserved NAD+-dependent histone
deacetylase that is necessary for caloric restriction-related lifespan extension. SIRT1, as an …

SIRT1 is an NAD+-dependent class III histone deacetylase that is abundantly expressed in
the kidney, where it modulates gene expression, apoptosis, energy homeostasis …

Significance: Antioxidant and redox signaling (ARS) events are regulated by critical
molecules that modulate antioxidants, reactive oxygen species (ROS) or reactive nitrogen …