Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes

ALJ Carr, DJ Perry, AL Lynam, S Chamala… - Diabetic …, 2020 - Wiley Online Library
Aims Misclassification of diabetes is common due to an overlap in the clinical features of
type 1 and type 2 diabetes. Combined diagnostic models incorporating clinical and …

Serum biomarkers for diagnosis and prediction of type 1 diabetes

L Yi, AC Swensen, WJ Qian - Translational Research, 2018 - Elsevier
Type 1 diabetes (T1D) culminates in the autoimmune destruction of the pancreatic βcells,
leading to insufficient production of insulin and development of hyperglycemia. Serum …

Classification of type 1 diabetes: A pathogenic and treatment-based classification

SK Patel, S Fourlanos, JR Greenfield - Diabetes & Metabolic Syndrome …, 2024 - Elsevier
Aim To improve the diagnosis and classification of patients who fail to satisfy current type 1
diabetes diagnostic criteria. Methods Review of the literature and current diagnostic …

Utility of polygenic scores for differentiating diabetes diagnosis among patients with atypical phenotypes of diabetes

LK Billings, Z Shi, J Wei, AS Rifkin… - The Journal of …, 2024 - academic.oup.com
Context Misclassification of diabetes type occurs in people with atypical presentations of
type 1 diabetes (T1D) or type 2 diabetes (T2D). Although current clinical guidelines suggest …

[HTML][HTML] Harmonization of immunoassays for biomarkers in diabetes mellitus

S Hörber, P Achenbach, E Schleicher, A Peter - Biotechnology advances, 2020 - Elsevier
Harmonization of biomarkers is important for the comparability of laboratory results as it
allows the definition of universal reference values and clinical decision limits. In diabetology …

[HTML][HTML] Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review

JL Felton, MJ Redondo, RA Oram, C Speake… - Communications …, 2024 - nature.com
Background Islet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and
staging, but heterogeneity exists in T1D development and presentation. We hypothesized …

Can clinical features be used to differentiate type 1 from type 2 diabetes? A systematic review of the literature

BM Shields, JL Peters, C Cooper, J Lowe, BA Knight… - BMJ open, 2015 - bmjopen.bmj.com
Objective Clinicians predominantly use clinical features to differentiate type 1 from type 2
diabetes yet there are no evidence-based clinical criteria to aid classification of patients …

The iDiabetes Platform: Enhanced Phenotyping of Patients with Diabetes for Precision Diagnosis, Prognosis and Treatment-study protocol for a cluster-randomised …

YY Lin, D Leith, M Abbott, R Barrett, S Bell… - medRxiv, 2024 - medrxiv.org
Introduction and Aim Diabetes is a global health emergency with increasing prevalence and
diabetes-associated morbidity and mortality. One of the challenges in optimising diabetes …

Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA

M Sanyoura, L Jacobsen, D Carmody… - The Journal of …, 2018 - academic.oup.com
Context Monogenic diabetes is thought to account for 2% of all diabetes cases, but most
patients receive misdiagnoses of type 1 or type 2 diabetes. To date, little is known about the …

Clinical heterogeneity of type 1 diabetes (T1D) found in Asia

Y Park, KA Wintergerst, Z Zhou - … /metabolism research and …, 2017 - Wiley Online Library
Diabetes mellitus among young patients in Asia is caused by a complex set of factors.
Although type 1 diabetes (T1D) remains the most common form of diabetes in children, the …