[HTML][HTML] C1s targeting antibodies inhibit the growth of cutaneous squamous carcinoma cells

L Nissinen, P Riihilä, K Viiklepp, V Rajagopal… - Scientific Reports, 2024 - nature.com
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer.
The incidence of cSCC is increasing globally and the prognosis of metastatic disease is …

Tumour‐cell‐derived complement components C1r and C1s promote growth of cutaneous squamous cell carcinoma

P Riihilä, K Viiklepp, L Nissinen… - British Journal of …, 2020 - academic.oup.com
Background The incidence of epidermal keratinocyte‐derived cutaneous squamous cell
carcinoma (cSCC) is increasing worldwide. Objectives To study the role of the complement …

[HTML][HTML] C1r upregulates production of matrix metalloproteinase-13 and promotes invasion of cutaneous squamous cell carcinoma

K Viiklepp, L Nissinen, M Ojalill, P Riihilä… - Journal of Investigative …, 2022 - Elsevier
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer,
with increasing incidence worldwide. Previous studies have shown the role of the …

[HTML][HTML] Complement component C3 and complement factor B promote growth of cutaneous squamous cell carcinoma

P Riihilä, L Nissinen, M Farshchian, M Kallajoki… - The American Journal of …, 2017 - Elsevier
Cutaneous squamous cell carcinoma (cSCC) is one of the most common metastatic skin
cancers with increasing incidence. We examined the roles of complement component C3 …

Complement C3a promotes proliferation, migration and stemness in cutaneous squamous cell carcinoma

Z Fan, J Qin, D Wang, S Geng - Journal of Cellular and …, 2019 - Wiley Online Library
Background Complement C3 has been shown to be highly expressed in cutaneous
squamous cell carcinoma (cSCC) tumour tissues and is correlated with tumour cell growth …

Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells

DK Chang, J Sui, S Geng, A Muvaffak, M Bai… - Molecular cancer …, 2012 - AACR
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of neoplastic disorders
characterized by clonally derived and skin-homing malignant T cells that express high level …

Effects of CSF1R-targeted chimeric antigen receptor-modified NK92MI & T cells on tumor-associated macrophages

P Zhang, S Zhao, C Wu, J Li, Z Li, C Wen, S Hu… - …, 2018 - Taylor & Francis
Tumor immunotherapy has shown great progress for the treatment of cancer; however, both
endogenous and exogenous T cells are inhibited by the immunosuppressive tumor …

[HTML][HTML] C3 drives inflammatory skin carcinogenesis independently of C5

WD Jackson, A Gulino, L Fossati-Jimack… - Journal of Investigative …, 2021 - Elsevier
Nonmelanoma skin cancer such as cutaneous squamous cell carcinoma (cSCC) is the most
common form of cancer and can occur as a consequence of DNA damage to the epithelium …

Genetic modification of T cells redirected toward CS1 enhances eradication of myeloma cells

J Chu, S He, Y Deng, J Zhang, Y Peng, T Hughes… - Clinical cancer …, 2014 - AACR
Purpose: Our goal is to test whether CS1 could be targeted by chimeric antigen receptor
(CAR) T cells to treat multiple myeloma (MM). Experimental Design: We generated a …

[HTML][HTML] TNB-486, a novel fully human bispecific CD19 x CD3 antibody that kills CD19-positive tumor cells with minimal cytokine secretion

H Malik, B Buelow, U Rangaswamy, A Balasubramani… - Blood, 2019 - Elsevier
Introduction The restricted expression of CD19 in the B-cell lineage makes it an attractive
target for the therapeutic treatment of B-cell malignancies. Many monoclonal antibodies and …