Mechanisms of taxane resistance
SM Maloney, CA Hoover, LV Morejon-Lasso… - Cancers, 2020 - mdpi.com
Simple Summary Drug resistance is prevalent in many types of cancer and decreases
patient survival. The taxanes are anti-mitotic chemotherapeutic agents, widely used since …
patient survival. The taxanes are anti-mitotic chemotherapeutic agents, widely used since …
Taxanes in cancer treatment: Activity, chemoresistance and its overcoming
Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …
Taxane resistance in breast cancer: mechanisms, predictive biomarkers and circumvention strategies
S Murray, E Briasoulis, H Linardou, D Bafaloukos… - Cancer treatment …, 2012 - Elsevier
BACKGROUND: Taxanes are established in the treatment of metastatic breast cancer (MBC)
and early breast cancer (EBC) as potent chemotherapy agents. However, their therapeutic …
and early breast cancer (EBC) as potent chemotherapy agents. However, their therapeutic …
Cellular mechanisms of resistance to anthracyclines and taxanes in cancer: intrinsic and acquired
AJ Chien, MM Moasser - Seminars in oncology, 2008 - Elsevier
Taxanes and anthracyclines are two of the most potent and broadly effective classes of
chemotherapeutic agents. However, resistance to these agents is common and significantly …
chemotherapeutic agents. However, resistance to these agents is common and significantly …
Therapeutic strategies to overcome taxane resistance in cancer
T Das, U Anand, SK Pandey, CR Ashby Jr… - Drug Resistance …, 2021 - Elsevier
One of the primary causes of attenuated or loss of efficacy of cancer chemotherapy is the
emergence of multidrug resistance (MDR). Numerous studies have been published …
emergence of multidrug resistance (MDR). Numerous studies have been published …
Molecular mechanisms of cancer drug resistance: emerging biomarkers and promising targets to overcome tumor progression
F Fontana, M Anselmi, P Limonta - Cancers, 2022 - mdpi.com
Cancer still represents a major global burden, being the second leading cause of death
worldwide [1]. Standard cancer treatments include surgery, radiotherapy and chemotherapy …
worldwide [1]. Standard cancer treatments include surgery, radiotherapy and chemotherapy …
Current perspectives on taxanes: Focus on their bioactivity, delivery and combination therapy
J Škubník, V Pavlíčková, T Ruml, S Rimpelová - Plants, 2021 - mdpi.com
Taxanes, mainly paclitaxel and docetaxel, the microtubule stabilizers, have been well known
for being the first-line therapy for breast cancer for more than the last thirty years. Moreover …
for being the first-line therapy for breast cancer for more than the last thirty years. Moreover …
[HTML][HTML] Taxane resistance in castration-resistant prostate cancer: mechanisms and therapeutic strategies
B Bumbaca, W Li - Acta Pharmaceutica Sinica B, 2018 - Elsevier
Despite its good initial response and significant survival benefit in patients with castration-
resistant prostate cancer (CRPC), taxane therapy inevitably encounters drug resistance in …
resistant prostate cancer (CRPC), taxane therapy inevitably encounters drug resistance in …
Paclitaxel and docetaxel resistance: molecular mechanisms and development of new generation taxanes
E Galletti, M Magnani, ML Renzulli… - ChemMedChem …, 2007 - Wiley Online Library
Taxanes represent one of the most promising classes of anticancer agents. Unfortunately,
their clinical success has been limited by the insurgence of cellular resistance, mainly …
their clinical success has been limited by the insurgence of cellular resistance, mainly …
Taxanes: promising anti-cancer drugs
NJ Fauzee, Z Dong, YL Wang - Asian Pac J Cancer Prev, 2011 - journal.waocp.org
Taxanes are amongst the most promising antitumor agents available at hand today, of
increasing importancein Asia given that cancer is now one of the major public health …
increasing importancein Asia given that cancer is now one of the major public health …