Brain inflammation generally accompanies and accelerates neurodegeneration. Here we
report a microglial mechanism in which polyglutamine binding protein 1 (PQBP1) senses …

Tau is an evolutionary conserved protein that promotes the assembly and stabilization of
microtubules in neuronal axons. Complex patterns of posttranslational modifications (PTMs) …

Neuroinflammation is one of the neuropathological hallmarks of Alzheimer's disease (AD)
and related tauopathies. Activated microglia spatially coexist with microtubule-associated …

To understand how neural-immune-associated genes and pathways contribute to
neurodegenerative disease pathophysiology, we performed a systematic functional genomic …

Alzheimer's Disease (AD) contributes to most cases of dementia. Its prominent
neuropathological features are the extracellular neuritic plaques and intercellular …

Tauopathies are a broad set of neurodegenerative dementias characterized by aggregation
of the tau protein into filamentous inclusions that can be found in neurons and glial cells …

Comorbidities that promote the progression of Alzheimer's disease (AD) remain to be
uncovered and evaluated in animal models. Because elderly individuals are vulnerable to …

Filamentous inclusions of the microtubule-associated protein, tau, define a variety of
neurodegenerative diseases known as tauopathies, including Alzheimer's disease (AD). To …

Alzheimer's Disease (AD) is a chronic neurodegenerative disorder and the most common
type of dementia (60–80% of cases). In 2016, nearly 44 million people were affected by AD …

Neurodegeneration, induced by misfolded tau protein, and neuroinflammation, driven by
glial cells, represent the salient features of Alzheimer's disease (AD) and related human …