It is well established that the immune response to sepsis is mediated by leukocytes
associated with the innate immune system. However, there is an emerging view that T …

Studies have indicated that there is a development of generalized immune dysfunction after
septic insult. However, the mechanisms responsible for these changes remain unclear …

Survival during sepsis requires both swift control of infectious organisms and tight regulation
of the associated inflammatory response. As the role of T cells in sepsis is somewhat …

Polymicrobial sepsis is associated with immunosuppression caused by the predominance of
anti-inflammatory mediators and profound loss of lymphocytes through apoptosis. Dendritic …

Background. Studies indicate that following septic insult there is development of generalized
immune dysfunction in T cells, B cells and phagocytes, which is thought to contribute to …

Murine polymicrobial sepsis is associated with a sustained reduction of dendritic cell (DC)
numbers in lymphoid organs and with a dysfunction of DC that is considered to mediate the …

Septic patients experience chronic immunosuppression resulting in enhanced susceptibility
to infections normally controlled by T cells. Clinical research on septic patients has shown …

Sepsis in mice possessing a functional human immune system causes extensive apoptotic
death of human immune effector cells and increases in both pro-and anti-inflammatory …

Our recent studies indicate that mice depleted of T cells that bear the αβ T-cell receptor (αβ T
cells) show less inflammation, less physiological dysfunction, and improved survival after …

Sepsis, an amplified immune response to systemic infection, is characterized by a transient
cytokine storm followed by chronic immune dysfunction. Consequently, sepsis survivors are …