Many pain states begin with damage to tissue and/or nerves in the periphery, leading to
enhanced transmitter release within the spinal cord and central sensitization. Manifestations …

Central sensitization represents an enhancement in the function of neurons and circuits in
nociceptive pathways caused by increases in membrane excitability and synaptic efficacy as …

Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and
synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central …

In Romeo and Juliet, Shakespeare argues that the names of things are not as important as
the thing itself and how we identify it. Hansson's Topical Review [4] asks whether central …

There is compelling evidence indicating that hyperalgesia, allodynia and ongoing pain
associated with peripheral nerve injury are due to changes in primary afferent neurons …

We will focus on spinal cord dorsal horn lamina I projection neurones, their supraspinal
targets and involvement in pain processing. These spinal cord neurons respond to tonic …

The spinal dorsal horn receives input from a wide variety of primary afferent axons, including
nociceptors, which respond to tissue-damaging stimuli from the skin, muscles, joints, and …

Pain research has uncovered important neuronal mechanisms that underlie clinically
relevant pain states such as inflammatory and neuropathic pain. Importantly, both the …

Publisher Summary Hyperalgesia and allodynia often aggravate pain for variable periods
after trauma, surgery, and inflammation. Pain that is induced by normally nonpainful stimuli …

This review summarizes recent findings on peripheral mechanisms underlying the
generation and inhibition of pain. The focus is on events occurring in peripheral injured …