Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour
TJS Shi, X Hua, X Lu, S Malkmus… - European Journal of …, 2006 - Wiley Online Library
Galanin is a 29‐amino‐acid peptide expressed in dorsal root ganglion (DRG) neurones and
spinal dorsal horn neurones. It affects pain threshold and has developmental and trophic …
spinal dorsal horn neurones. It affects pain threshold and has developmental and trophic …
Mice deficient for galanin receptor 2 have decreased neurite outgrowth from adult sensory neurons and impaired pain‐like behaviour
SA Hobson, FE Holmes, NCH Kerr… - Journal of …, 2006 - Wiley Online Library
Expression of the neuropeptide galanin is markedly up‐regulated within the adult dorsal root
ganglia (DRG) following peripheral nerve injury. We have previously demonstrated that …
ganglia (DRG) following peripheral nerve injury. We have previously demonstrated that …
Hyperalgesia and increased neuropathic pain-like response in mice lacking galanin receptor 1 receptors
KH Blakeman, JX Hao, XJ Xu, AS Jacoby, J Shine… - Neuroscience, 2003 - Elsevier
The neuropeptide galanin may have a role in modulation of nociception, particularly after
peripheral nerve injury. The effect of galanin is mediated by at least three subtypes of …
peripheral nerve injury. The effect of galanin is mediated by at least three subtypes of …
The participation of galanin in pain processing at the spinal level
Abstract Galanin, a 29-amino-acid peptide expressed in dorsal root ganglia (DRG) and
spinal dorsal horn interneurones, is regulated by nerve injury and peripheral inflammation …
spinal dorsal horn interneurones, is regulated by nerve injury and peripheral inflammation …
Evidence for galanin receptors in primary sensory neurones and effect of axotomy and inflammation
USING in situ hybridization, mRNA coding for the galanin R1 receptor (GAL-R1) was
demonstrated in> 20% of all lumbar 4 and 5 dorsal root ganglion neurone profiles, mainly …
demonstrated in> 20% of all lumbar 4 and 5 dorsal root ganglion neurone profiles, mainly …
Phenotyping of sensory and sympathetic ganglion neurons of a galanin-overexpressing mouse—possible implications for pain processing
P Brumovsky, K Hygge-Blakeman, MJ Villar… - Journal of Chemical …, 2006 - Elsevier
The distribution of galanin was studied in the lumbar 5 dorsal root ganglia (DRGs) and
spinal cord, superior cervical ganglia (SCGs), and skin of transgenic mice overexpressing …
spinal cord, superior cervical ganglia (SCGs), and skin of transgenic mice overexpressing …
Generation and phenotypic characterization of a galanin overexpressing mouse
K Holmberg, E Kuteeva, P Brumovsky, U Kahl… - Neuroscience, 2005 - Elsevier
In most parts of the peripheral nervous system galanin is expressed at very low levels. To
further understand the functional role of galanin, a mouse overexpressing galanin under the …
further understand the functional role of galanin, a mouse overexpressing galanin under the …
Galanin and spinal nociceptive mechanisms: recent results from transgenic and knock-out models
Z Wiesenfeld-Hallin, XJ Xu, JN Crawley, T Hökfelt - Neuropeptides, 2005 - Elsevier
Genetically modified mice with transgenic overexpression of galanin or depletion of genes
for galanin or galanin receptors have become available, providing a new approach for …
for galanin or galanin receptors have become available, providing a new approach for …
Galanin over-expression decreases the development of neuropathic pain-like behaviors in mice after partial sciatic nerve injury
K Hygge-Blakeman, P Brumovsky, JX Hao, XJ Xu… - Brain research, 2004 - Elsevier
The neuropeptide galanin may have a role in modulation of nociception, particularly after
peripheral nerve injury. Here we assessed the development of neuropathic pain-like …
peripheral nerve injury. Here we assessed the development of neuropathic pain-like …
Activation of the galanin receptor 2 in the periphery reverses nerve injury-induced allodynia
Background: Galanin is expressed at low levels in the intact sensory neurons of the dorsal
root ganglia with a dramatic increase after peripheral nerve injury. The neuropeptide is also …
root ganglia with a dramatic increase after peripheral nerve injury. The neuropeptide is also …