Mass spectrometry imaging highlights dynamic patterns of lipid co‐expression with Aβ plaques in mouse and human brains

HX Huang, P Inglese, J Tang, R Yagoubi… - Journal of …, 2024 - Wiley Online Library
Lipids play crucial roles in the susceptibility and brain cellular responses to Alzheimer's
disease (AD) and are increasingly considered potential soluble biomarkers in cerebrospinal …

Spatial neurolipidomics at the single amyloid-β plaque level in postmortem human Alzheimer's disease brain

W Michno, A Bowman, D Jha, K Minta… - ACS Chemical …, 2024 - ACS Publications
Lipid dysregulations have been critically implicated in Alzheimer's disease (AD) pathology.
Chemical analysis of amyloid-β (Aβ) plaque pathology in transgenic AD mouse models has …

[HTML][HTML] Comparative lipidomic analysis of mouse and human brain with Alzheimer disease

RB Chan, TG Oliveira, EP Cortes, LS Honig… - Journal of Biological …, 2012 - ASBMB
Lipids are key regulators of brain function and have been increasingly implicated in
neurodegenerative disorders including Alzheimer disease (AD). Here, a systems-based …

[HTML][HTML] Lipid profiling of Alzheimer's disease brain highlights enrichment in glycerol (phospho) lipid, and sphingolipid metabolism

S Akyol, Z Ugur, A Yilmaz, I Ustun, SKK Gorti, K Oh… - Cells, 2021 - mdpi.com
Alzheimer's disease (AD) is reported to be closely linked with abnormal lipid metabolism. To
gain a more comprehensive understanding of what causes AD and its subsequent …

Lipid imaging of Alzheimer's disease pathology

J Hanrieder - Journal of Neurochemistry, 2024 - Wiley Online Library
Alzheimer's disease (AD) affects one in eight individuals over 65 and poses an immense
societal challenge. AD pathology is characterized by the formation of beta‐amyloid plaques …

[PDF][PDF] Lipid profiling of Alzheimer's disease brain highlights enrichment in glycerol (phospho) lipid, and sphingolipid metabolism. Cells. 2021; 10: 2591

S Akyol, Z Ugur, A Yilmaz, I Ustun, SKK Gorti… - DOI: https://doi. org …, 2021 - academia.edu
Alzheimer's disease (AD) is reported to be closely linked with abnormal lipid metabolism. To
gain a more comprehensive understanding of what causes AD and its subsequent …

Dysregulation of lipids in Alzheimer's disease and their role as potential biomarkers

MW Wong, N Braidy, A Poljak, R Pickford… - Alzheimer's & …, 2017 - Elsevier
The brain is highly enriched in lipids, and an intensive study of these lipids may be
informative, not only of normal brain function but also of changes with age and in disease. In …

Multimodal chemical imaging of amyloid plaque polymorphism reveals Aβ aggregation dependent anionic lipid accumulations and metabolism

W Michno, I Kaya, S Nyström, L Guerard… - Analytical …, 2018 - ACS Publications
Amyloid plaque formation constitutes one of the main pathological hallmarks of Alzheimer's
disease (AD) and is suggested to be a critical factor driving disease pathogenesis …

Structural amyloid plaque polymorphism is associated with distinct lipid accumulations revealed by trapped ion mobility mass spectrometry imaging

W Michno, PM Wehrli, S Koutarapu… - Journal of …, 2022 - Wiley Online Library
Understanding of Alzheimer's disease (AD) pathophysiology requires molecular assessment
of how key pathological factors, specifically amyloid β (Aβ) plaques, influence the …

Spatially resolved mass spectrometry analysis of amyloid plaque‐associated lipids

M Blank, C Hopf - Journal of Neurochemistry, 2021 - Wiley Online Library
Over the last 10 years, considerable technical advances in mass spectrometry (MS)‐based
bioanalysis have enabled the investigation of lipid signatures in neuropathological …