Dynamic DNA methylation across diverse human cell lines and tissues
As studies of DNA methylation increase in scope, it has become evident that methylation has
a complex relationship with gene expression, plays an important role in defining cell types …
a complex relationship with gene expression, plays an important role in defining cell types …
DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns
Background DNA epigenetic modifications, such as methylation, are important regulators of
tissue differentiation, contributing to processes of both development and cancer. Profiling the …
tissue differentiation, contributing to processes of both development and cancer. Profiling the …
A DNA methylation map of human cancer at single base-pair resolution
Although single base-pair resolution DNA methylation landscapes for embryonic and
different somatic cell types provided important insights into epigenetic dynamics and cell …
different somatic cell types provided important insights into epigenetic dynamics and cell …
Cytosine methylation profiling of cancer cell lines
DNA-methylation changes in human cancer are complex and vary between the different
types of cancer. Capturing this epigenetic variability in an atlas of DNA-methylation changes …
types of cancer. Capturing this epigenetic variability in an atlas of DNA-methylation changes …
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm
DNA methylation plays key roles in diverse biological processes such as X chromosome
inactivation, transposable element repression, genomic imprinting, and tissue-specific gene …
inactivation, transposable element repression, genomic imprinting, and tissue-specific gene …
Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
Background Dynamic changes to the epigenome play a critical role in establishing and
maintaining cellular phenotype during differentiation, but little is known about the normal …
maintaining cellular phenotype during differentiation, but little is known about the normal …
Large-scale structure of genomic methylation patterns
RA Rollins, F Haghighi, JR Edwards, R Das… - Genome …, 2006 - genome.cshlp.org
The mammalian genome depends on patterns of methylated cytosines for normal function,
but the relationship between genomic methylation patterns and the underlying sequence is …
but the relationship between genomic methylation patterns and the underlying sequence is …
Comparison of methyl-DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain (MBD) protein capture for genome-wide DNA methylation analysis reveal …
DNA methylation primarily occurs at CpG dinucleotides in mammals and is a common
epigenetic mark that plays a critical role in the regulation of gene expression. Profiling DNA …
epigenetic mark that plays a critical role in the regulation of gene expression. Profiling DNA …
Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping
Genomic DNA methylation profiles exhibit substantial variation within the human population,
with important functional implications for gene regulation. So far little is known about the …
with important functional implications for gene regulation. So far little is known about the …
Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue-and individual-specific DNA methylation patterns
HM Byun, KD Siegmund, F Pan… - Human molecular …, 2009 - academic.oup.com
DNA methylation is known to be associated with cell differentiation, aging, disease and
cancer. There exists an expanding base of knowledge regarding tissue-specific DNA …
cancer. There exists an expanding base of knowledge regarding tissue-specific DNA …