Breathing in vitro: Designs and applications of engineered lung models
R Nossa, J Costa, L Cacopardo… - Journal of tissue …, 2021 - journals.sagepub.com
The aim of this review is to provide a systematic design guideline to users, particularly
engineers interested in developing and deploying lung models, and biologists seeking to …
engineers interested in developing and deploying lung models, and biologists seeking to …
Recent advances in lung-on-a-chip technology for modeling respiratory disease
Tissue engineering approaches, including those to functional lung tissues, are finely honed
by the inclusion of upgraded devices that mimic biophysical and biochemical features in …
by the inclusion of upgraded devices that mimic biophysical and biochemical features in …
Bio-inspired, efficient, artificial lung employing air as the ventilating gas
JA Potkay, M Magnetta, A Vinson, B Cmolik - Lab on a Chip, 2011 - pubs.rsc.org
Artificial lungs have recently been utilized to rehabilitate patients suffering from lung
diseases. However, significant advances in gas exchange, biocompatibility, and portability …
diseases. However, significant advances in gas exchange, biocompatibility, and portability …
Advances and challenges in recapitulating human pulmonary systems: at the cusp of biology and materials
The aim of this review is to provide an overview of physiologically relevant microengineered
lung-on-a-chip (LoC) platforms for a variety of different biomedical applications with …
lung-on-a-chip (LoC) platforms for a variety of different biomedical applications with …
Modeling the lung: Design and development of tissue engineered macro-and micro-physiologic lung models for research use
JE Nichols, JA Niles, SP Vega… - Experimental …, 2014 - journals.sagepub.com
Respiratory tract specific cell populations, or tissue engineered in vitro grown human lung,
have the potential to be used as research tools to mimic physiology, toxicology, pathology …
have the potential to be used as research tools to mimic physiology, toxicology, pathology …
Respiratory physiology on a chip
Our current understanding of respiratory physiology and pathophysiological mechanisms of
lung diseases is often limited by challenges in developing in vitro models faithful to the …
lung diseases is often limited by challenges in developing in vitro models faithful to the …
Development of lung tissue models and their applications
N Petpiroon, W Netkueakul, K Sukrak, C Wang, Y Liang… - Life Sciences, 2023 - Elsevier
The lungs are important organs that play a critical role in the development of specific
diseases, as well as responding to the effects of drugs, chemicals, and environmental …
diseases, as well as responding to the effects of drugs, chemicals, and environmental …
A new immortalized human alveolar epithelial cell model to study lung injury and toxicity on a breathing lung-on-chip system
A Sengupta, N Roldan, M Kiener, L Froment… - Frontiers in …, 2022 - frontiersin.org
The evaluation of inhalation toxicity, drug safety and efficacy assessment, as well as the
investigation of complex disease pathomechanisms, are increasingly relying on in vitro lung …
investigation of complex disease pathomechanisms, are increasingly relying on in vitro lung …
Lung bioengineering: physical stimuli and stem/progenitor cell biology interplay towards biofabricating a functional organ
PN Nonaka, JJ Uriarte, N Campillo, VR Oliveira… - Respiratory …, 2016 - Springer
A current approach to obtain bioengineered lungs as a future alternative for transplantation
is based on seeding stem cells on decellularized lung scaffolds. A fundamental question to …
is based on seeding stem cells on decellularized lung scaffolds. A fundamental question to …
Advanced pathophysiology mimicking lung models for accelerated drug discovery
Background Respiratory diseases are the 2 nd leading cause of death globally. The current
treatments for chronic lung diseases are only supportive. Very few new classes of …
treatments for chronic lung diseases are only supportive. Very few new classes of …