Islet transplantation for type 1 diabetes treatment has been limited by the need for lifelong
immunosuppression regimens. This challenge has prompted the development of …

Macroencapsulation technology has been an attractive topic in the field of treatment for Type
1 diabetes due to mechanical stability, versatility, and retrievability of the macro‐capsule …

Type 1 diabetes (T1D) is characterized by destruction of glucose-responsive insulin-
producing pancreatic β-cells and exhibits immune infiltration of pancreatic islets, where CD8 …

Abstract Purpose of Review There is considerable interest in using macroencapsulation
devices as a delivery strategy for transplanting insulin-producing cells. This review aims to …

Cellular therapies for type-1 diabetes can leverage cell encapsulation to dispense with
immunosuppression. However, encapsulated islet cells do not survive long, particularly …

Stem cell derived insulin producing cells or islets have shown promise in reversing Type 1
Diabetes (T1D), yet successful transplantation currently necessitates long‐term modulation …

Type 1 diabetes is an autoimmune disease in which the immune system attacks insulin-
producing beta cells of pancreatic islets. Type 1 diabetes can be treated with islet …

Highlights•Islet encapsulation strategies are classified based on islet-to-host
distance.•Material design, cell biology and immunology determine encapsulation success.• …

Pancreatic islet transplantation improves metabolic control and prevents complications in
patients with brittle type 1 diabetes (T1D). However, chronic immunosuppression is required …

Transplantation of encapsulated islets can cure diabetes without immunosuppression, but
oxygen supply limitations can cause failure. We investigated a retrievable …