The kisspeptin-GnRH pathway in human reproductive health and disease

K Skorupskaite, JT George… - Human reproduction …, 2014 - academic.oup.com
BACKGROUND The discovery of kisspeptin as key central regulator of GnRH secretion has
led to a new level of understanding of the neuroendocrine regulation of human reproduction …

[HTML][HTML] The role of kisspeptin in the control of the hypothalamic-pituitary-gonadal axis and reproduction

Q Xie, Y Kang, C Zhang, Y Xie, C Wang, J Liu… - Frontiers in …, 2022 - frontiersin.org
The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given
people a novel understanding of the neuroendocrine regulation in human reproduction …

[HTML][HTML] Comprehensive review on kisspeptin and its role in reproductive disorders

H Clarke, WS Dhillo, CN Jayasena - Endocrinology and …, 2015 - ncbi.nlm.nih.gov
Kisspeptin has recently emerged as a key regulator of the mammalian reproductive axis. It is
known that kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of …

The role of kisspeptin in the control of gonadotrophin secretion

AK Roseweir, RP Millar - Human reproduction update, 2009 - academic.oup.com
BACKGROUND Kisspeptins, and their cognate receptor gpr-54, were first found to regulate
the hypothalamic–pituitary–gonadal (HPG) axis in 2003, when two groups demonstrated …

Kisspeptin antagonists: unraveling the role of kisspeptin in reproductive physiology

RP Millar, AK Roseweir, JA Tello, RA Anderson… - Brain research, 2010 - Elsevier
Kisspeptin has recently been identified as a key neuroendocrine gatekeeper of reproduction
and is essential for the initiation of human puberty and maintenance of adult reproduction …

Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility

VM Navarro, M Tena-Sempere - Nature Reviews Endocrinology, 2012 - nature.com
The neurohormonal control of reproduction involves a hierarchical network of central and
peripheral signals in the hypothalamic–pituitary–gonadal (HPG) axis. Development and …

Interactions between kisspeptins and neurokinin B

VM Navarro - Kisspeptin Signaling in Reproductive Biology, 2013 - Springer
Reproductive function is tightly regulated by an intricate network of central and peripheral
factors; however, the precise mechanism triggering critical reproductive events, such as …

[HTML][HTML] The role of kisspeptin in female reproduction

SZ Nejad, FR Tehrani… - International journal of …, 2017 - ncbi.nlm.nih.gov
Results The kisspeptin system (KISS1/G protein-coupled receptor-54, GPR54) has recently
been addressed as an essential gatekeeper of puberty onset and gonadotropin secretion …

Kisspeptin administration to women: a window into endogenous kisspeptin secretion and GnRH responsiveness across the menstrual cycle

YM Chan, JP Butler, VF Sidhoum… - The Journal of …, 2012 - academic.oup.com
Context: Kisspeptin is the most powerful known stimulus of GnRH-induced LH secretion
across mammalian species. However, the effects of kisspeptin are just being explored, and …

Kisspeptin treatment induces gonadotropic responses and rescues ovulation in a subset of preclinical models and women with polycystic ovary syndrome

A Romero-Ruiz, K Skorupskaite, F Gaytan… - Human …, 2019 - academic.oup.com
STUDY QUESTION Can kisspeptin treatment induce gonadotrophin responses and
ovulation in preclinical models and anovulatory women with polycystic ovary syndrome …