Integrating network pharmacology and experimental models to identify notoginsenoside R1 ameliorates atherosclerosis by inhibiting macrophage NLRP3 …

J Yu, J Hu, M Baldini, H Lei, L Li, S Luo, J Wu… - Journal of Natural …, 2024 - Springer
Atherosclerosis is a cardiovascular disease, accounting for the most common mortality
cause worldwide. Notoginsenoside R1 (NGR1) is a characteristic saponin of Radix …

Notoginsenoside R1 regulates ischemic myocardial lipid metabolism by activating the AKT/mTOR signaling pathway

W Lei, Y Yan, Y Ma, M Jiang, B Zhang… - Frontiers in …, 2022 - frontiersin.org
Ischemic heart diseases are responsible for more than one-third of all deaths worldwide.
Radix notoginseng is widely used to treat ischemic heart disease in China and other Asian …

Notoginsenoside R1 attenuates atherosclerotic lesions in ApoE deficient mouse model

C Jia, M Xiong, P Wang, J Cui, X Du, Q Yang… - PLoS …, 2014 - journals.plos.org
Aims Atherosclerosis is the primary cause of cardiovascular diseases and stroke. The
current study evaluated the interventional effects of a naturally occurring compound …

[HTML][HTML] Exploring the anti-atherosclerosis mechanism of ginsenoside Rb1 by integrating network pharmacology and experimental verification

L Hou, Z Zou, Y Wang, H Pi, Z Yuan, Q He… - Aging (Albany …, 2024 - ncbi.nlm.nih.gov
Ginsenoside Rb1 is the major active constituent of ginseng, which is widely used in
traditional Chinese medicine for the atherosclerosis treatment by anti-inflammatory, anti …

Notoginsenoside R1 Ameliorate High-Fat-Diet and Vitamin D3-Induced Atherosclerosis via Alleviating Inflammatory Response, Inhibiting Endothelial Dysfunction, and …

L Ma, Y Gao, G Yang, L Zhao, Z Zhao… - Drug Design …, 2024 - Taylor & Francis
Aim The inflammatory response plays a pivotal role in the occurrence, progression, and
plaque formation of atherosclerosis. The study was performed to investigate the impacts of …

Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway

X Liu, Y Xu, S Cheng, X Zhou, F Zhou, P He… - Frontiers in …, 2021 - frontiersin.org
Inflammation and apoptosis of vascular endothelial cells play a key role in the occurrence
and development of atherosclerosis (AS), and the AMPK/mTOR/Nrf2 signaling pathway …

Integrative network pharmacology and experimental verification to reveal the anti-inflammatory mechanism of ginsenoside Rh4

KI To, ZX Zhu, YN Wang, GA Li, YM Sun, Y Li… - Frontiers in …, 2022 - frontiersin.org
Inflammation is an innate immune response to infection, and it is the main factor causing
bodily injury and other complications in the pathological process. Ginsenoside Rh4 (G-Rh4) …

Notoginsenoside R1 alleviates oxidized low-density lipoprotein-induced apoptosis, inflammatory response, and oxidative stress in HUVECS through modulation of …

J Zhao, L Cui, J Sun, Z Xie, L Zhang, Z Ding, X Quan - Cellular Signalling, 2020 - Elsevier
Background: Atherosclerosis is a common reason for acute cardio-cerebral vascular
diseases. The purpose of this study was to clarify the functional effects of Notoginsenoside …

Notoginsenoside R1 attenuates atherosclerotic lesions in ApoE deficient mouse model.

JCL Jia ChengLin, XMQ Xiong MinQi… - 2014 - cabidigitallibrary.org
Aims: Atherosclerosis is the primary cause of cardiovascular diseases and stroke. The
current study evaluated the interventional effects of a naturally occurring compound …

Notoginsenoside R1 inhibits oxidized low-density lipoprotein induced inflammatory cytokines production in human endothelial EA. hy926 cells

P Su, S Du, H Li, Z Li, W Xin, W Zhang - European journal of pharmacology, 2016 - Elsevier
Abstract Notoginsenoside R1 (NG-R1), a unique and main active ingredient of Panax
notoginseng, has been described to exhibit anti-inflammatory activity. However, its protective …