Despite existing therapy, patients with heart failure (HF) experience substantial morbidity
and mortality, highlighting the urgent need to identify novel pathophysiological mechanisms …

The high energy demands of the heart are met primarily by the mitochondrial oxidation of
fatty acids and glucose. However, in heart failure there is a decrease in cardiac …

The ketone bodies beta-hydroxybutyrate and acetoacetate are hepatically produced
metabolites catabolized in extrahepatic organs. Ketone bodies are a critical cardiac fuel and …

Ketone bodies can become a major source of adenosine triphosphate production during
stress to maintain bioenergetic homeostasis in the brain, heart, and skeletal muscles. In the …

Background: Accumulating evidence suggests that the failing heart reprograms fuel
metabolism toward increased utilization of ketone bodies and that increasing cardiac ketone …

Objectives. The present study was designed to assess whether blood ketone bodies are
elevated in congestive heart failure (CHF) and whether ketonemia is related to the …

Aims Upregulation of ketone body (β-hydroxybutyrate, βHB) utilization has been
documented in human end-stage heart failure (HF), but is unclear if this is due to intrinsic …

Accumulating evidence suggests that the failing heart reverts energy metabolism toward
increased utilization of ketone bodies. Despite many discrepancies in the literature …

Background High levels of ketone bodies are associated with improved survival as observed
with regular exercise, caloric restriction, and—most recently—treatment with sodium …

Background: Previous studies have shown beneficial effects of acute infusion of the primary
ketone body, β-hydroxybutyrate, in heart failure (HF). However, whether chronic elevations …