Tetraspanins play important roles in normal (eg cell adhesion, motility, activation, and
proliferation) and pathological conditions (eg metastasis and viral infection). Tetraspanins …

CD151, a member of the tetraspanin family of proteins, forms a stable complex with integrin
α3β1 and regulates integrin-mediated cell-substrate adhesion. However, the molecular …

Integrin α3β1 potently promotes cell motility on its ligands, laminin-332 and laminin-511, and
this may help to explain why α3β1 has repeatedly been linked to breast carcinoma …

The basement membrane protein laminin-332 (laminin-5) mediates both stable cell
adhesion and rapid cell migration and thus has the potential to either restrain or promote …

The tetraspanin CD151 forms a stoichiometric complex with integrin α3β1 and regulates its
endocytosis. We observed that down-regulation of CD151 in various epithelial cell lines …

CD151 is a cell surface protein that belongs to the tetraspanin superfamily. It forms
complexes with the laminin-binding integrinsα3β1, α6β1 and α6β4 and is codistributed with …

Transmembrane proteins of the tetraspanin superfamily are associated with various
integrins and modulate their function. We performed mutagenesis analysis to establish …

The α3β1 integrin shows strong, stoichiometric, direct lateral association with the tetraspanin
CD151. As shown here, an extracellular CD151 site (QRD194–196) is required for strong …

Upon plating on basement membrane Matrigel, NIH3T3 cells formed an anastomosing
network of cord-like structures, inhibitable by anti-α6β1 integrin antibodies. For NIH3T3 cells …

Tetraspanins associate on the cell membrane with several transmembrane proteins,
including members of the integrin superfamily. The tetraspanin CD9 has been implicated in …