Simple Summary The dissemination of cancer cells from their original location to distant
organs where they grow, a process called metastasis, causes more than 90% of cancer …

Angiogenesis inhibitors have now been tested for more than a decade. Most approaches
have focused on blockade of the vascular endothelial growth factor (VEGF) pathway, and …

Abstract The angiopoietins Ang1 (ANGPT1) and Ang2 (ANGPT2) are secreted factors that
bind to the endothelial cell–specific receptor tyrosine kinase Tie2 (TEK) and regulate …

Tie2 is an endothelial cell-specific receptor tyrosine kinase, whose activation is positively
and negatively modulated by angiopoietin-1 and angiopoietin-2, respectively. Angiopoietin …

Abstract The angiopoietin-1 (Ang1)/Tie2 signaling pathway is known to play an important
role in the regulation of vascular maturation and maintenance of vessel integrity. In this …

The tyrosine kinase receptor Tie2 was initially identified as a specific vascular growth factor
that governed several properties of endothelial cells under both physiological and …

Abstract Angiopoietins (ANG-1 and ANG-2) and their TIE-2 receptor tyrosine kinase have
wide-ranging effects on tumor malignancy that includes angiogenesis, inflammation, and …

The distinct roles of angiopoietin (Ang)-1 and Ang2, counteracting ligands for the
endothelium-specific Tie2 receptor, in tumor development and progression have remained …

The endothelial tyrosine kinase receptor Tie1 remains poorly characterized, largely owing to
its orphan receptor status. Global Tie1 inactivation causes late embryonic lethality, thereby …

Tumor-infiltrating myeloid cells convey proangiogenic programs that counteract the efficacy
of antiangiogenic therapy. Here, we show that blocking angiopoietin-2 (ANG2), a TIE2 …