A review of the potential mechanisms of action of baclofen in alcohol use disorder
R De Beaurepaire - Frontiers in Psychiatry, 2018 - frontiersin.org
Baclofen, a GABA-B receptor agonist, is a promising treatment for alcohol use disorder
(AUD). Its mechanism of action in this condition is unknown. GABA-B receptors interact with …
(AUD). Its mechanism of action in this condition is unknown. GABA-B receptors interact with …
Safety and efficacy of baclofen in the treatment of alcohol-dependent patients
G Addolorato, L Leggio - Current pharmaceutical design, 2010 - ingentaconnect.com
Preclinical studies show that antagonism of the GABAB receptor may represent an effective
neuropharmacological approach to treat alcohol dependence. Consistent with preclinical …
neuropharmacological approach to treat alcohol dependence. Consistent with preclinical …
A deeper insight into how GABA-B receptor agonism via baclofen may affect alcohol seeking and consumption: lessons learned from a human laboratory investigation
Previous studies suggest that GABA-B receptor agonism may represent an effective
pharmacological approach to treat addictive disorders. Baclofen is a selective GABA-B …
pharmacological approach to treat addictive disorders. Baclofen is a selective GABA-B …
Effectiveness and safety of baclofen in the treatment of alcohol dependent patients
L Leggio, JC Garbutt… - CNS & Neurological …, 2010 - ingentaconnect.com
Both preclinical and clinical research studies have shown the GABAB receptor agonist
baclofen represents a promising treatment for alcohol dependence. Preliminary clinical …
baclofen represents a promising treatment for alcohol dependence. Preliminary clinical …
Using baclofen to explore GABA-B receptor function in alcohol dependence: insights from pharmacokinetic and pharmacodynamic measures
CF Durant, LM Paterson, S Turton, SJ Wilson… - Frontiers in …, 2018 - frontiersin.org
Background: The role of GABA-B neurotransmission in addiction has recently received
increased attention, with clinical trials indicating that baclofen, a GABA-B receptor agonist …
increased attention, with clinical trials indicating that baclofen, a GABA-B receptor agonist …
GABAB receptor ligands for the treatment of alcohol use disorder: preclinical and clinical evidence
The present paper summarizes the preclinical and clinical studies conducted to define the
“anti-alcohol” pharmacological profile of the prototypic GABAB receptor agonist, baclofen …
“anti-alcohol” pharmacological profile of the prototypic GABAB receptor agonist, baclofen …
Targeting the GABAB Receptor for the Treatment of Alcohol Use Disorder
Accumulating lines of experimental and clinical evidence suggest that the prototypic,
orthosteric GABA type B (GABA B) receptor agonist, baclofen, may possess therapeutic …
orthosteric GABA type B (GABA B) receptor agonist, baclofen, may possess therapeutic …
GABAB receptor as therapeutic target for drug addiction: from baclofen to positive allosteric modulators
The present paper summarizes experimental and clinical data indicating the therapeutic
potential of the GABAB receptor agonist, baclofen, in the treatment of alcohol use disorder …
potential of the GABAB receptor agonist, baclofen, in the treatment of alcohol use disorder …
Baclofen in the treatment of patients with alcohol use disorder and other mental health disorders
A limited number of medications are approved to treat Alcohol Use Disorder (AUD).
Furthermore, the magnitude of their therapeutic effect is relatively modest, suggesting the …
Furthermore, the magnitude of their therapeutic effect is relatively modest, suggesting the …
Is baclofen a revolutionary medication in alcohol addiction management? Review and recent updates
MA Gorsane, O Kebir, G Hache, L Blecha… - Substance …, 2012 - journals.sagepub.com
Baclofen, a γ-aminobutyric acid (GABA)-B receptor agonist, represents a promising drug in
alcohol addiction management. Animal models have shown its action at various stages of …
alcohol addiction management. Animal models have shown its action at various stages of …