All the cells in our bodies are derived from the germ cells of our parents, just as our own
germ cells become the bodies of our children. The integrity of the genetic information …

Birth defects, de novo genetic diseases, and chromosomal abnormality syndromes occur
in∼ 5% of all live births, and affected children suffer from a broad range of lifelong health …

Fifty years ago, the Environmental Mutagen Society (now Environmental Mutagenesis and
Genomics Society) was founded with a laser‐focus on germ cell mutagenesis and the …

Individuals who smoke generally do so with the knowledge of potential consequences to
their own health. What is rarely considered are the effects of smoking on their future children …

After more than 80 years of searching for human germ‐cell mutagens, I think that sufficient
evidence already exists for a number of agents to be so considered, and definitive …

Heritable mutations may result in a wide variety of detrimental outcomes, from embryonic
lethality to genetic disease in the offspring. Despite this, today's commonly used test …

There is considerable evidence that inhaled toxicants such as cigarette smoke can cause
both irreversible changes to the genetic material (DNA mutations) and putatively reversible …

A mutagenesis moonshot addressing the influence of the environment on our genetic
wellbeing was launched just 2 months before astronauts landed on the moon. Its impetus …

Introduction: This paper was written in response to a request from the US National Cancer
Institute. The goal is to discuss some research directions related to establishing tobacco …

The health burden from tobacco smoking results almost entirely from inhalation of the
components of smoke, although this is not widely known. The primary benefit of smoking is …