Hypoxia-inducible factor (HIF) controls an extensive range of adaptive responses to hypoxia.
To better understand this transcriptional cascade we performed genome-wide chromatin …

Hypoxia‐inducible factor (HIF) is the major transcriptional regulator of cellular responses to
hypoxia. The two principal HIF‐α isoforms, HIF‐1α and HIF‐2α, are progressively stabilized …

Background Hypoxia-inducible factor 1 (HIF-1) plays a key role in cellular adaptation to
hypoxia. To better understand the determinants of HIF-1 binding and transactivation, we …

Hypoxia-inducible transcription factors (HIFs) mediate the cellular response to hypoxia. HIF-
DNA binding triggers a transcriptional program that acts to both restore oxygen homeostasis …

Hypoxia‐inducible factor (HIF) directs an extensive transcriptional cascade that transduces
numerous adaptive responses to hypoxia. Pan‐genomic analyses, using chromatin …

Transcriptional responses to hypoxia are primarily mediated by hypoxia-inducible factors
(HIFs), HIF-1α and HIF-2α. The HIF-1α and HIF-2α subunits are structurally similar in their …

Hypoxia inducible factor (HIF) transcription factors are crucial for regulating a variety of
cellular activities in response to oxygen stress (hypoxia). In this study, we determine the …

The hypoxia-inducible transcription factor (HIF) controls (in an oxygen-dependent manner)
the expression of a large number of genes whose products are involved in the response of …

The basic helix-loop-helix-Per-ARNT-Sim–proteins hypoxia-inducible factor (HIF)-1α and
HIF-2α are the principal regulators of the hypoxic transcriptional response. Although highly …

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix transcription
factor that regulates genes whose products play key roles in maintaining O2homeostasis …