[HTML][HTML] The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2
FJ Stott, S Bates, MC James, BB McConnell… - The EMBO …, 1998 - embopress.org
The two distinct proteins encoded by the CDKN2A locus are specified by translating the
common second exon in alternative reading frames. The product of the α transcript, p16 …
common second exon in alternative reading frames. The product of the α transcript, p16 …
The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53
KD Robertson, PA Jones - Molecular and cellular biology, 1998 - Taylor & Francis
The INK4a/ARF locus encodes two proteins involved in tumor suppression in a manner
virtually unique in mammalian cells. Distinct first exons, driven from separate promoters …
virtually unique in mammalian cells. Distinct first exons, driven from separate promoters …
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
The INK4a-ARF locus encodes two unrelated proteins that both function in tumor
suppression. p16 INK4a binds to and inhibits the activity of CDK4 and CDK6, and ARF …
suppression. p16 INK4a binds to and inhibits the activity of CDK4 and CDK6, and ARF …
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
DE Ouelle, F Zindy, RA Ashmun, CJ Sherr - Cell, 1995 - Elsevier
The INK4a (MTS1, CDKN2) gene encodes an inhibitor (p16INK4a) of the cyclin D-
dependent kinases CDK4 and CDK6 that blocks them from phosphorylating the …
dependent kinases CDK4 and CDK6 that blocks them from phosphorylating the …
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
T Kamijo, JD Weber, G Zambetti… - Proceedings of the …, 1998 - National Acad Sciences
The INK4a-ARF locus encodes two proteins, p16INK4a and p19ARF, that restrain cell
growth by affecting the functions of the retinoblastoma protein and p53, respectively …
growth by affecting the functions of the retinoblastoma protein and p53, respectively …
Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus
KD Robertson, PA Jones - Oncogene, 1999 - nature.com
The INK4a/ARF locus on human chromosome 9p resides at the nexus of two critical cell
cycle regulatory pathways, the p53 pathway and the retinoblastoma (pRb) gene pathway …
cycle regulatory pathways, the p53 pathway and the retinoblastoma (pRb) gene pathway …
[HTML][HTML] The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
J Pomerantz, N Schreiber-Agus, NJ Liégeois… - Cell, 1998 - cell.com
The INK4a gene encodes two distinct growth inhibitors—the cyclin-dependent kinase
inhibitor p16 Ink4a, which is a component of the Rb pathway, and the tumor suppressor p19 …
inhibitor p16 Ink4a, which is a component of the Rb pathway, and the tumor suppressor p19 …
[HTML][HTML] Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19 ARF
T Kamijo, F Zindy, MF Roussel, DE Quelle, JR Downing… - Cell, 1997 - cell.com
The INK4a tumor suppressor locus encodes p16 INK4a, an inhibitor of cyclin D-dependent
kinases, and p19 ARF, an alternative reading frame protein that also blocks cell proliferation …
kinases, and p19 ARF, an alternative reading frame protein that also blocks cell proliferation …
Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus
S Llanos, PA Clark, J Rowe, G Peters - Nature cell biology, 2001 - nature.com
The alternative product of the human INK4a/ARF locus, p14 ARF, has the potential to act as
a tumour suppressor by binding to and inhibiting the p53 antagonist MDM2. Current models …
a tumour suppressor by binding to and inhibiting the p53 antagonist MDM2. Current models …
Arf induces p53-dependent and-independent antiproliferative genes
ML Kuo, EJ Duncavage, R Mathew, W Den Besten… - Cancer Research, 2003 - AACR
The tumor suppressor p19Arf (p14ARF in humans), encoded by the Ink4a/Arf locus, is
mutated, deleted, or silenced in many forms of cancer. p19Arf induces growth arrest by …
mutated, deleted, or silenced in many forms of cancer. p19Arf induces growth arrest by …