At least half of all amputations occur in people with diabetes, most commonly because of an
infected diabetic foot ulcer. A thorough understanding of the causes and management of …

Diabetes mellitus is a global epidemic. Peripheral neuropathy and peripheral vascular
disease are complications of diabetes mellitus and the primary causative factors for foot …

In patients with long-standing, poorly controlled diabetes and peripheral neuropathy, a red,
hot, swollen foot without open ulceration should raise the suspicion of Charcot …

Foot ulcers are a significant complication of diabetes mellitus and often precede lower-
extremity amputation. The most frequent underlying etiologies are neuropathy, trauma …

Background: Hospital-based studies have shown that mortality rates in individuals with
diabetic foot ulcers are about twice those observed in individuals with diabetes without foot …

Foot ulcerations and their sequelae remain a major source of morbidity for patients with
diabetes mellitus. Often leading to infection, osteomyelitis, or gangrene, these lesions have …

Diabetic foot ulcers are a devastating component of diabetes progression and are caused by
loss of glycemic control, peripheral neuropathy, peripheral vascular disease, and …

The lifetime risk for diabetic patients to develop a diabetic foot ulcer (DFU) is 25%. In these
patients, the risk of amputation is increased and the outcome deteriorates. More than 50% of …

Importance Approximately 18.6 million people worldwide are affected by a diabetic foot ulcer
each year, including 1.6 million people in the United States. These ulcers precede 80% of …

At some time in their life, 15% of people with diabetes develop foot ulcers, which are highly
susceptible to infection (1). These may spread rapidly leading to overwhelming tissue …