Calcium and iron absorption—mechanisms and public health relevance

B Lönnerdal - International Journal for Vitamin and Nutrition …, 2010 - econtent.hogrefe.com
Studies on human subjects have shown that calcium (Ca) can inhibit iron (Fe) absorption,
regardless of whether it is given as Ca salts or in dairy products. This has caused concern as …

The effect of calcium on iron absorption

SR Lynch - Nutrition research reviews, 2000 - cambridge.org
The experimental and epidemiological evidence demonstrating that Ca inhibits Fe
absorption was reviewed, with the objectives of estimating the potential impact of variations …

[HTML][HTML] Functional and molecular responses of human intestinal Caco-2 cells to iron treatment

J Tallkvist, CL Bowlus, B Lönnerdal - The American journal of clinical …, 2000 - Elsevier
Background: Divalent metal transporter 1 (DMT1), HFE, and stimulator of iron transport (SFT)
are transmembrane proteins that have been implicated in the regulation of iron homeostasis …

Regulatory effects of Cu, Zn, and Ca on Fe absorption: the intricate play between nutrient transporters

N Scheers - Nutrients, 2013 - mdpi.com
Iron is an essential nutrient for almost every living organism because it is required in a
number of biological processes that serve to maintain life. In humans, recycling of senescent …

Inhibitory effect of calcium on non-heme iron absorption may be related to translocation of DMT-1 at the apical membrane of enterocytes

BAV Thompson, PA Sharp, R Elliott… - Journal of agricultural …, 2010 - ACS Publications
Many studies show that calcium reduces iron absorption from single meals, but the
underlying mechanism is not known. We tested the hypothesis that calcium alters the …

Coordinate expression and localization of iron and zinc transporters explain iron–zinc interactions during uptake in Caco-2 cells: implications for iron uptake at the …

V Iyengar, R Pullakhandam, KM Nair - The Journal of nutritional …, 2012 - Elsevier
Iron and zinc have diverse and important physiological functions. Yet, the mechanism of
their absorption at the intestine remains controversial and is confounded by the fact that …

[HTML][HTML] Inhibitory effects of dietary calcium on the initial uptake and subsequent retention of heme and nonheme iron in humans: comparisons using an intestinal …

ZKF Roughead, CA Zito, JR Hunt - The American journal of clinical nutrition, 2005 - Elsevier
Background: Calcium is the only reported dietary inhibitor of both heme-and nonheme-iron
absorption. It has been proposed that the 2 forms of iron enter a common pool in the …

[HTML][HTML] Molecular mechanisms involved in intestinal iron absorption

P Sharp, SK Srai - World journal of gastroenterology: WJG, 2007 - ncbi.nlm.nih.gov
Iron is an essential trace metal in the human diet due to its obligate role in a number of
metabolic processes. In the diet, iron is present in a number of different forms, generally …

Interaction of calcium with the human divalent metal-ion transporter-1

A Shawki, B Mackenzie - Biochemical and biophysical research …, 2010 - Elsevier
Iron deficiency is the most prevalent micronutrient deficiency worldwide. Whereas dietary
calcium is known to reduce the bioavailability of iron, the molecular basis of this interaction …

New perspectives on the regulation of iron absorption via cellular zinc concentrations in humans

M Knez, RD Graham, RM Welch… - Critical reviews in food …, 2017 - Taylor & Francis
abstract Iron deficiency is the most prevalent nutritional deficiency, affecting more than 30%
of the total world's population. It is a major public health problem in many countries around …