Blood pressure is determined by cardiac output and peripheral vascular resistance. The L-
type voltage-gated Ca2+ (Cav1. 2) channel in small arteries and arterioles plays an …

Hypertension is a major cardiovascular risk factor. Of the many processes involved in the
pathophysiology of hypertension, vascular damage due to oxidative stress (excess …

Systemic arterial hypertension is a highly prevalent cardiovascular risk factor that causes
significant morbidity and mortality, and is becoming an increasingly common health problem …

An increase in intracellular Ca2+ concentration ([Ca2+] i) controls virtually all endothelial
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …

Reactive oxygen species (ROS) produced in the neuronal, renal, and vascular systems not
only influence cardiovascular physiology but are also strongly implicated in pathological …

Recent evidence suggests that oxidant stress plays a major role in several aspects of
vascular biology. Oxygen free radicals are implicated as important factors in signaling …

Vascular T-type Ca2+ channels (CaV3. 1 and CaV3. 2) play a key role in arterial tone
development. This study investigated whether this conductance is a regulatory target of …

Aims As cardiovascular disease is characterized by reduced nitric oxide bioavailability, our
aim was to determine the impact of this change on the mechanism underlying vascular tone …

Signaling cascades initiated or regulated by calcium (Ca2+), reactive oxygen (ROS), and
nitrogen (RNS) species are essential to diverse physiological and pathological processes in …

Background: Disruption of redox signaling is a common pathophysiological mechanism
observed in several diseases. In hypertension, oxidative stress, resulted either from …