Background The covalent linkage between DNA and the active site tyrosine of
topoisomerase I can be stabilized by chemotherapeutic agents, adjacent DNA lesions, or …

Topoisomerase II is a ubiquitous enzyme that removes knots and tangles from the genetic
material by generating transient double‐strand DNA breaks. While the enzyme cannot …

Type II DNA topoisomerases function as homodimeric enzymes in transiently cleaving
double-stranded DNA to catalyze unlinking and unknotting reactions. The dimeric enzyme …

Accidental or drug-induced interruption of the breakage and reunion cycle of eukaryotic
topoisomerase I (Top1) yields complexes in which the active site tyrosine of the enzyme is …

ABSTRACT DNA topoisomerases play critical roles in a wide range of cellular processes by
altering DNA topology to facilitate replication, transcription, and chromosome segregation …

Topoisomerase I plays a vital role in relieving tension on DNA strands generated during
replication. However if trapped by camptothecin or other DNA damage, topoisomerase …

DNA topoisomerases play essential roles in many DNA metabolic processes. It has been
suggested that topoisomerases play an essential role in DNA repair. Topoisomerases can …

DNA topoisomerase I (Top1) catalyzes the relaxation of supercoiled DNA by a mechanism of
transient DNA strand cleavage characterized by the formation of a phosphotyrosyl bond …

The Saccharomyces cerevisiaeTOP3 gene encodes the type IA topoisomerase (Top3p) that
is highly conserved in evolution. Deletion of TOP3 leads to a reduction in cell viability, hyper …

Eukaryotic DNA topoisomerase I catalyzes the relaxation of supercoiled DNA through a
concerted mechanism of DNA strand breakage and religation. The cytotoxic activity of …