Hydroxylation increases the neurotoxic potential of BDE-47 to affect exocytosis and calcium homeostasis in PC12 cells
MML Dingemans, A De Groot… - Environmental …, 2008 - ehp.niehs.nih.gov
Background Oxidative metabolism, resulting in the formation of hydroxylated polybrominated
diphenyl ether (PBDE) metabolites, may enhance the neurotoxic potential of brominated …
diphenyl ether (PBDE) metabolites, may enhance the neurotoxic potential of brominated …
Bromination pattern of hydroxylated metabolites of BDE-47 affects their potency to release calcium from intracellular stores in PC12 cells
MML Dingemans, HJ Heusinkveld… - Environmental …, 2010 - ehp.niehs.nih.gov
Background Brominated flame retardants, including the widely used polybrominated
diphenyl ethers (PBDEs), have been detected in humans, raising concern about possible …
diphenyl ethers (PBDEs), have been detected in humans, raising concern about possible …
2, 2′, 4, 4′-tetrabromodiphenyl ether (BDE-47) induces wide metabolic changes including attenuated mitochondrial function and enhanced glycolysis in PC12 cells
Polybrominated diphenyl ethers (PBDEs) are extensively used as brominated flame
retardants in various factory products. As environmental pollutants, the adverse effects of …
retardants in various factory products. As environmental pollutants, the adverse effects of …
The brominated flame retardant BDE-47 causes oxidative stress and apoptotic cell death in vitro and in vivo in mice
LG Costa, C Pellacani, K Dao, TJ Kavanagh, PJ Roque - Neurotoxicology, 2015 - Elsevier
Polybrominated diphenyl ethers (PBDEs), used for decades as flame retardants, have
become widespread environmental contaminants. Exposure is believed to occur primarily …
become widespread environmental contaminants. Exposure is believed to occur primarily …
Neonatal exposure to brominated flame retardant BDE-47 reduces long-term potentiation and postsynaptic protein levels in mouse hippocampus
MML Dingemans, GMJ Ramakers… - Environmental …, 2007 - ehp.niehs.nih.gov
Background Increasing environmental levels of brominated flame retardants raise concern
about possible adverse effects, particularly through early developmental exposure …
about possible adverse effects, particularly through early developmental exposure …
Hexabromocyclododecane inhibits depolarization-induced increase in intracellular calcium levels and neurotransmitter release in PC12 cells
MML Dingemans, HJ Heusinkveld… - Toxicological …, 2009 - academic.oup.com
Environmental levels of the brominated flame retardant (BFR) hexabromocyclododecane
(HBCD) have been increasing. HBCD has been shown to cause adverse effects on learning …
(HBCD) have been increasing. HBCD has been shown to cause adverse effects on learning …
In vitro effects of environmentally relevant polybrominated diphenyl ether (PBDE) congeners on calcium buffering mechanisms in rat brain
CG Coburn, MC Currás-Collazo… - Neurochemical research, 2008 - Springer
Polybrominated diphenyl ethers (PBDEs) are widely used as additive flame-retardants and
have been detected in human blood, adipose tissue, and breast milk. Developmental and …
have been detected in human blood, adipose tissue, and breast milk. Developmental and …
Cytotoxicity and gene expression profiling of two hydroxylated polybrominated diphenyl ethers in human H295R adrenocortical carcinoma cells
R Song, TL Duarte, GM Almeida, PB Farmer… - Toxicology Letters, 2009 - Elsevier
Polybrominated diphenyl ethers (PBDEs) are commonly used as flame retardants in a
variety of commercial and household products. They have been detected in the environment …
variety of commercial and household products. They have been detected in the environment …
Polybrominated Diphenyl Ether (PBDE) Effects in Rat Neuronal Cultures: 14C-PBDE Accumulation, Biological Effects, and Structure-Activity Relationships
PRS Kodavanti, TR Ward, G Ludewig… - Toxicological …, 2005 - academic.oup.com
Polybrominated diphenyl ethers (PBDEs), widely used as flame-retardants, are now
recognized as globally distributed pollutants, and are detected in most environmental and …
recognized as globally distributed pollutants, and are detected in most environmental and …
Proteomic evaluation of neonatal exposure to 2, 2′, 4, 4′, 5-pentabromodiphenyl ether
H Alm, B Scholz, C Fischer, K Kultima… - Environmental …, 2006 - ehp.niehs.nih.gov
Exposure to the brominated flame retardant 2, 2′, 4, 4′, 5-pentabromodiphenyl ether
(PBDE-99) during the brain growth spurt disrupts normal brain development in mice and …
(PBDE-99) during the brain growth spurt disrupts normal brain development in mice and …
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