Chronic lymphocytic leukemia (CLL) is caused by the accumulation of malignant B cells due
to a defect in apoptosis and the presence of small population of proliferating cells principally …

Chronic lymphocytic leukemia (CLL) cells display features consistent with a defect in
apoptosis and exhibit prolonged survival in vivo. Survival of these malignant cells is …

Chronic lymphocytic leukemia (CLL) cells extensively interact with and depend on their
surrounding tumor microenvironment (TME). The TME encompasses a heterogeneous array …

The tissue microenvironment in chronic lymphocytic leukemia (CLL) has an increasingly
recognized role in disease progression, but the molecular mechanisms of cross talk …

Abstract Chronic Lymphocytic Leukemia (CLL) is a malignancy of mature B lymphocytes
which are highly dependent on interactions with the tissue microenvironment for their …

B-cell chronic lymphocytic leukemia (CLL), which is the most common lymphoproliferative
disorder, displays characteristics consistent with a defect in programmed cell death and …

Interactions between malignant B lymphocytes and the tissue microenvironment play a
major role in the pathogenesis of chronic lymphocytic leukemia (CLL) and other B-cell …

Intrinsic factors such as genetic lesions, anti-apoptotic proteins, and aberrant signaling
networks within leukemia cells have long been the main focus of chronic lymphocytic …

Abstract Chronic Lymphocytic Leukemia (CLL) is a B cell malignancy characterized by the
accumulation of mature monoclonal CD5-positive B cells in the blood, secondary lymphoid …

The tumor microenvironment (TME) plays an essential role in the development, growth, and
survival of the malignant B-cell clone in chronic lymphocytic leukemia (CLL). Within the …