State of the art: the immunomodulatory role of MSCs for osteoarthritis

DG Kwon, MK Kim, YS Jeon, YC Nam, JS Park… - International journal of …, 2022 - mdpi.com
Osteoarthritis (OA) has generally been introduced as a degenerative disease; however, it
has recently been understood as a low-grade chronic inflammatory process that could …

Immunomodulation of MSCs and MSC-derived extracellular vesicles in osteoarthritis

X Zhao, Y Zhao, X Sun, Y Xing, X Wang… - … in Bioengineering and …, 2020 - frontiersin.org
Osteoarthritis (OA) has become recognized as a low-grade inflammatory state. Inflammatory
infiltration of the synovium by macrophages, T cells, B cells, and other immune cells is often …

Research progress in the use of mesenchymal stem cells and their derived exosomes in the treatment of osteoarthritis

H Yu, Y Huang, L Yang - Ageing research reviews, 2022 - Elsevier
Osteoarthritis (OA), as a common orthopedic disease with cartilage injury as its main
pathological feature, has a complex pathogenesis and existing medical technology remains …

Advances in mesenchymal stem cell therapy for osteoarthritis: from preclinical and clinical perspectives

Z Lv, X Cai, Y Bian, Z Wei, W Zhu, X Zhao, X Weng - Bioengineering, 2023 - mdpi.com
The prevalence of osteoarthritis (OA), a degenerative disorder of joints, has substantially
increased in recent years. Its key pathogenic hallmarks include articular cartilage …

[HTML][HTML] Mesenchymal stem cell related therapies for cartilage lesions and osteoarthritis

R Zhang, J Ma, J Han, W Zhang… - American journal of …, 2019 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is a common degenerative joint disease characterized by cartilage
degradation, synovitis, subchondral bone sclerosis and osteophyte formation. Current …

Exosomes in osteoarthritis: Updated insights on pathogenesis, diagnosis, and treatment

WJ Fan, D Liu, LY Pan, WY Wang, YL Ding… - Frontiers in Cell and …, 2022 - frontiersin.org
Osteoarthritis (OA) has remained a prevalent public health problem worldwide over the past
decades. OA is a global challenge because its specific pathogenesis is unclear, and no …

[HTML][HTML] Revolutionizing osteoarthritis treatment: How mesenchymal stem cells hold the key

R Tian, S Su, Y Yu, S Liang, C Ma, Y Jiao… - Biomedicine & …, 2024 - Elsevier
Osteoarthritis (OA) is a multifaceted disease characterized by imbalances in extracellular
matrix metabolism, chondrocyte and synoviocyte senescence, as well as inflammatory …

Expression of exosomal microRNAs during chondrogenic differentiation of human bone mesenchymal stem cells

H Sun, S Hu, Z Zhang, J Lun, W Liao… - Journal of cellular …, 2019 - Wiley Online Library
The aim of the current study was to compare the expression of microRNAs (miRNAs) in
exosomes derived from human bone mesenchymal stem cells (hBMSCs) with and without …

The efficacy of stem cells secretome application in osteoarthritis: a systematic review of in vivo studies

M Bousnaki, A Bakopoulou, A Kritis, P Koidis - Stem Cell Reviews and …, 2020 - Springer
Abstract Purpose Mesenchymal stem cells (MSCs) have appeared as a promising
regenerative cell-based therapeutic, for degenerative conditions, such as OA, while the …

Mesenchymal stem cell-derived exosomes and MicroRNAs in cartilage regeneration: biogenesis, efficacy, miRNA enrichment and delivery

JB Foo, QH Looi, CW How, SH Lee, ME Al-Masawa… - Pharmaceuticals, 2021 - mdpi.com
Exosomes are the small extracellular vesicles secreted by cells for intercellular
communication. Exosomes are rich in therapeutic cargos such as microRNA (miRNA), long …