Sigma receptors are non-opiate/non-phencyclidine receptors that bind progesterone and/or
heme and also several unrelated xenobiotics/chemicals. They reside in the plasma …

Abstract Sigma‐1 receptor (S1R) regulates reactive oxygen species (ROS) accumulation via
nuclear factor erythroid 2‐related factor 2 (NRF2), which plays a vital role in ferroptosis …

The Sigma Receptor 1 (sig-1R) is a protein present in numerous normal tissues, such as
brain, retina, lens, liver, lung, heart, but also in many tumor lines. Its amino acid sequence is …

After decades of research, the sigma-1 receptor (Sig-1R)'s structure, and molecular functions
are being unveiled. Sig-1R is an integral endoplasmic reticulum (ER) membrane protein …

Abstract Sigma-1 receptor (S1R) is a calcium-sensitive, ligand-operated receptor chaperone
present on the endoplasmic reticulum (ER) membrane. S1R plays an important role in ER …

Cell excitability is tightly regulated by the activity of ion channels that allow for the passage
of ions across cell membranes. Ion channel activity is controlled by different mechanisms …

Introduction: S2R (sigma-2 receptor)/Pgrmc1 (progesterone receptor membrane component
1) is a cytochrome-related protein that binds directly to heme and various pharmacological …

A controversial relationship between sigma-2 and progesterone receptor membrane
component 1 (PGRMC1) proteins, both representing promising targets for the therapy and …

Sigma-1 receptor ligands have been long expected to serve as drugs for treatment of human
diseases such as neurodegenerative disorders, depression, idiopathic pain, drug abuse …

This review analyzes the current scientific literature on the role of the Sigma1R chaperone in
the pathogenesis of depressive disorders and pharmacodynamics of antidepressants. As a …