The treatment of a brain glioma is still one of the most difficult challenges in oncology. To
effectively treat brain glioma and reduce the side effects, drugs must be transported across …

A dual targeting delivery system was developed to completely conquer the two barriers that
glioma treatment faces: the blood–brain barrier (BBB) and the brain–glioma barrier …

Though there has been substantial advancement in the knowledge about tumour
development and treatment in the past 40 years, the prognosis of brain glioblastoma is still …

Now it is well evidenced that tumor growth is a comprehensive result of multiple pathways,
and glioma parenchyma cells and stroma cells are closely associated and mutually …

The extent of resection is a significant prognostic factor in glioma patients. However, the
maximum safe resection level is difficult to determine due to the inherent infiltrative character …

Gliomas are hard to treat because of the two barriers involved: the blood–brain barrier and
blood–tumor barrier. In this study, a dual-targeting ligand, angiopep-2, and an activatable …

Chemotherapy is an indispensable auxiliary treatment for glioma but highly limited by the
existence of both blood–brain barrier (BBB) and blood–brain tumor barrier (BBTB). The …

Polymeric nanoparticles (PNPs) may efficiently deliver in vivo therapeutics to tumors when
conjugated to specific targeting agents. Gint4. T aptamer specifically recognizes platelet …

Chemotherapy is still the main adjuvant strategy after surgery in glioblastoma therapy. As
the main obstacles of chemotherapeutic drugs for glioblastoma treatment, the blood brain …

Glioma is a fatal disease with limited treatment options and very short survival. Although
chemotherapy is one of the most important strategies in glioma treatment, it remains …