[HTML][HTML] The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes
Summary Peptidoglycan recognition protein 1 (PGLYRP1) is a pattern-recognition protein
that mediates antibacterial actions and innate immune responses. Its expression and role in …
that mediates antibacterial actions and innate immune responses. Its expression and role in …
LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways
L Yang, CC Liu, H Zheng, T Kanekiyo, Y Atagi… - Journal of …, 2016 - Springer
Background Neuroinflammation is characterized by microglial activation and the increased
levels of cytokines and chemokines in the central nervous system (CNS). Recent evidence …
levels of cytokines and chemokines in the central nervous system (CNS). Recent evidence …
The role of NLRP3 inflammasome for microglial response to peripheral inflammation
O Garaschuk - Neural regeneration research, 2021 - journals.lww.com
Systemic inflammation is often accompanied by adaptive responses mediated by the central
nervous system, such as lack of motivation and attention, fatigue, malaise, irritation or even …
nervous system, such as lack of motivation and attention, fatigue, malaise, irritation or even …
NLRP3 inflammasome and glia maturation factor coordinately regulate neuroinflammation and neuronal loss in MPTP mouse model of Parkinson's disease
H Javed, R Thangavel, GP Selvakumar… - International …, 2020 - Elsevier
Neuroinflammation plays an active role in the pathogenesis of several neurodegenerative
diseases, including Parkinson's disease (PD). Earlier studies from this laboratory showed …
diseases, including Parkinson's disease (PD). Earlier studies from this laboratory showed …
Innate immune activation in neurodegenerative disease
The triggering of innate immune mechanisms is emerging as a crucial component of major
neurodegenerative diseases. Microglia and other cell types in the brain can be activated in …
neurodegenerative diseases. Microglia and other cell types in the brain can be activated in …
Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity
Peripheral peptidolgycan (PGN) is present within antigen-presenting cells in the central
nervous system (CNS) of multiple sclerosis (MS) patients, possibly playing a role in …
nervous system (CNS) of multiple sclerosis (MS) patients, possibly playing a role in …
Hypoxia inducible factor-1α regulates microglial innate immune memory and the pathology of Parkinson's disease
H Dong, X Zhang, Y Duan, Y He, J Zhao… - Journal of …, 2024 - Springer
Neuroinflammation is one of the core pathological features of Parkinson's disease (PD).
Innate immune cells play a crucial role in the progression of PD. Microglia, the major innate …
Innate immune cells play a crucial role in the progression of PD. Microglia, the major innate …
The role of inflammation in neurodegenerative diseases
Neuroinflammation is a critical pathophysiological process implicated in the development of
neurodegenerative diseases. It involves the activation of immune cells in the brain …
neurodegenerative diseases. It involves the activation of immune cells in the brain …
LRP1 expression in microglia is protective during CNS autoimmunity
Multiple sclerosis is a devastating neurological disorder characterized by the autoimmune
destruction of the central nervous system myelin. While T cells are known orchestrators of …
destruction of the central nervous system myelin. While T cells are known orchestrators of …
Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture
Microglial inflammation driven by the NACHT, LRR and PYD domain‐containing protein 3
(NLRP3) inflammasome contributes to brain disease and is a therapeutic target. Most …
(NLRP3) inflammasome contributes to brain disease and is a therapeutic target. Most …