Once-weekly subcutaneous semaglutide improves fatty liver disease in patients with type 2 diabetes: a 52-week prospective real-life study

S Volpe, G Lisco, M Fanelli, D Racaniello, V Colaianni… - Nutrients, 2022 - mdpi.com
Background. Nonalcoholic fatty liver disease (NAFLD) is commonly observed in patients
with type 2 diabetes (T2D). Semaglutide, a glucagon-like peptide 1 receptor agonist, may …

Efficacy and safety of oral semaglutide in patients with non‐alcoholic fatty liver disease complicated by type 2 diabetes mellitus: A pilot study

T Arai, M Atsukawa, A Tsubota, H Ono, T Kawano… - JGH …, 2022 - Wiley Online Library
Abstract Background and Aim This study aimed to clarify the efficacy and safety of oral
semaglutide treatment in patients with non‐alcoholic fatty liver disease (NAFLD) …

Role of semaglutide in the treatment of nonalcoholic fatty liver disease or non-alcoholic steatohepatitis: a systematic review and meta-analysis

S Bandyopadhyay, S Das, SS Samajdar… - Diabetes & Metabolic …, 2023 - Elsevier
Aim This systematic review and meta-analysis was conducted to evaluate the efficacy and
safety of 24 weeks of semaglutide treatment in patients with non-alcoholic fatty liver disease …

[HTML][HTML] Efficacy and safety of semaglutide in non-alcoholic fatty liver disease

K Zhu, R Kakkar, D Chahal, EM Yoshida… - World Journal of …, 2023 - ncbi.nlm.nih.gov
BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic
liver disease. The prevalence and disease burden of NAFLD are projected to exponentially …

Effect of semaglutide on liver enzymes and markers of inflammation in subjects with type 2 diabetes and/or obesity

P Newsome, S Francque, S Harrison… - Alimentary …, 2019 - Wiley Online Library
Background Obesity and type 2 diabetes are drivers of non‐alcoholic fatty liver disease
(NAFLD). Glucagon‐like peptide‐1 analogues effectively treat obesity and type 2 diabetes …

Oral semaglutide improves body composition and preserves lean mass in patients with type 2 diabetes: a 26-week prospective real-life study

S Volpe, G Lisco, M Fanelli, D Racaniello… - Frontiers in …, 2023 - frontiersin.org
Background Oral semaglutide is the first glucagon-like peptide-1 receptor agonist (GLP-
1RA) designed for oral administration; it offers a promising opportunity to facilitate an early …

Randomised clinical trial: semaglutide versus placebo reduced liver steatosis but not liver stiffness in subjects with non‐alcoholic fatty liver disease assessed by …

A Flint, G Andersen, P Hockings… - Alimentary …, 2021 - Wiley Online Library
Background Glucagon‐like peptide‐1 receptor agonists may be a treatment option in
patients with non‐alcoholic fatty liver disease (NAFLD). Aims To investigate the effects of …

Semaglutide ameliorates metabolism and hepatic outcomes in an NAFLD mouse model

S Niu, S Chen, X Chen, Q Ren, L Yue, X Pan… - Frontiers in …, 2022 - frontiersin.org
Purpose The aim of this study was to evaluate changes in body weight, liver weight, blood
glucose, liver injury markers, pro-inflammatory factors and oxidative stress marker levels in …

Semaglutide has beneficial effects on non-alcoholic steatohepatitis in Ldlr-/-. Leiden mice

JA Inia, G Stokman, MC Morrison, N Worms… - International Journal of …, 2023 - mdpi.com
Semaglutide, a glucagon-like peptide-1 receptor agonist, is an antidiabetic medication that
has recently been approved for the treatment of obesity as well. Semaglutide is postulated to …

Once-weekly semaglutide induces an early improvement in body composition in patients with type 2 diabetes: a 26-week prospective real-life study

S Volpe, G Lisco, D Racaniello, M Fanelli, V Colaianni… - Nutrients, 2022 - mdpi.com
Background: Body weight (BW) loss is an essential therapeutic goal in type 2 diabetes
(T2D). Glucagon-like peptide-1 receptor agonists are effective in reducing BW, but their …