As major active ingredients of the traditional Chinese medicine motherwort, stachydrine and
leonurine were found to have protective effects against cerebral ischemia. However, their …

Ischemic stroke (IS) is characterized by the sudden loss of blood circulation to an area of the
brain, resulting in a corresponding loss of neurologic function. It has been a worldwide …

Effective intervention against ischemic stroke requires delivery of potent neuroprotective
drugs to the brain. Tanshinone IIA (TSIIA), the major bioactive ingredient extracted from the …

Dihydrotanshinone I (DHT) is a natural component in Salvia miltiorrhiza and has been
widely researched for its multiple bioactivities. However, poor solubility and biocompatibility …

Cerebral ischemia/reperfusion (I/R) injury is a key reason for the poor prognosis of ischemic
stroke. As only a few neuroprotective medications for cerebral I/R injury have been applied …

Abstract Huang-Lian-Jie-Du-Decoction (HLJDD, Oren-gedoku-to in Japanese) is commonly
used in traditional Chinese medicine (TCM) to treat ischemic stroke. This study investigated …

A series of novel NBP-TMP hybrids with neuroprotective effects were designed and
synthesized for the treatment of ischemic stroke. The anti-cerebral ischemic activity of these …

Ischemic stroke continues to be a major global health problem associated with considerable
mortality and morbidity. Thus, it is still targeted by researchers for developing new strategies …

Background Stroke could cause long-term disability, even mortality around the world.
Recently, Sodium tanshinone IIA sulfonate (STS), identified from Salvia miltiorrhiza Bunge …

This study investigated the neuroprotective effect of salvianolic acids (SA) against
ischemia/reperfusion (I/R) injury, and explored whether the neuroprotection was dependent …