Background Most primary prostate cancers are multifocal with individual tumors harboring
different aggressiveness; however, the genomic heterogeneity among these tumors is poorly …

From a clinical, morphological and molecular perspective, prostate cancer is a
heterogeneous disease. Primary prostate cancers are often multifocal, having …

Background Next-generation sequencing is revealing genomic heterogeneity in localized
prostate cancer (CaP). Incomplete sampling of CaP multiclonality has limited the …

Herein we provide a detailed molecular analysis of the spatial heterogeneity of clinically
localized, multifocal prostate cancer to delineate new oncogenes or tumor suppressors. We …

Although prostate cancer is the most common malignancy to affect men in the Western
world, the molecular mechanisms underlying its development and progression remain …

Background Global disparities in prostate cancer (PCa) incidence highlight the urgent need
to identify genomic abnormalities in prostate tumors in different ethnic populations including …

Genome-wide DNA sequencing was used to decrypt the phylogeny of multiple samples from
distinct areas of cancer and morphologically normal tissue taken from the prostates of three …

Prostate cancers are highly prevalent in the developed world, with inheritable risk
contributing appreciably to tumour development. Genomic heterogeneity within individual …

Prostate cancer is clinically heterogeneous, ranging from indolent to lethal disease.
Expression profiling previously defined three subtypes of prostate cancer, one (subtype-1) …

Prostate cancer is a paradigm tumor model for heterogeneity in almost every sense. Its
clinical, spatial, and morphological heterogeneity divided by the high-level molecular …