Various biomarkers targeting cell-free DNA (cfDNA) and circulating proteins have been
tested for pan-cancer detection. Oncofetal chondroitin sulfate (ofCS), which distinctively …

Chondroitin sulfate (CS) is the placental receptor for the VAR2CSA malaria protein,
expressed at the surface of infected erythrocytes during Plasmodium falciparum infection …

Many tumors express proteoglycans modified with oncofetal chondroitin sulfate
glycosaminoglycan chains (ofCS), which are normally restricted to the placenta. However …

Introduction: Head and neck squamous cell carcinoma (HNSCC) is a devastating and
deadly disease, largely because it is diagnosed in late stage. Cure rates, currently at 50 …

Solid tumors remain a major challenge for targeted therapeutic intervention strategies such
as antibody-drug conjugates and immunotherapy. At a minimum, clear and actionable solid …

We provide here an example of clinical application of functional glycoproteomics for cancer
diagnosis. Sialyl Lewis a and sialyl Lewis x glycotopes, which are the specific ligands for …

Much research has been performed over the past several decades in an attempt to conquer
cancer. Tissue biopsy is the conventional method for gathering biological materials to …

Single-chain glycoprotein CD44 is a major cell surface receptor for hyaluronan and
mediates epithelial cell adhesion by its involvement in cell-cell and cell-matrix interactions …

CD44 is a heavily glycosylated membrane receptor playing a key role in cell adhesion,
signal transduction and cytoskeleton remodelling. It is also one of the most studied …

Objective The extracellular matrix (ECM) of ovarian cancer may provide a number of
potential biomarkers. Chondroitin sulfate (CS), a class of sulfated polysaccharides, is …