Pancreatic ductal adenocarcinoma (PDA) is the most lethal of common human
malignancies, with no truly effective therapies for advanced disease. Preclinical studies …

Pancreatic ductal adenocarcinoma (PDA) constitutes a lethal disease that affects> 30,000
people annually in the United States. Deregulation of Hedgehog signaling has been …

Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease characterized by
an extensive fibroinflammatory stroma, which includes abundant cancer-associated …

Pancreatic cancer, mostly pancreatic ductal adenocarcinoma (PDAC), is a leading cause of
cancer-related death in the US, with a dismal median survival of 6 months. Thus, there is an …

Pancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer related
death. The urgent need for effective therapies is highlighted by the lack of adequate …

Hedgehog (Hh) signaling is deregulated in multiple human cancers including pancreatic
ductal adenocarcinoma (PDA). Because KRAS mutation represents one of the earliest …

Pancreatic cancer, a hypovascular and highly desmoplastic cancer, is characterized by
tumor expression of Hedgehog (HH) ligands that signal to fibroblasts in the surrounding …

The Hedgehog (Hh) pathway has been implicated in pancreatic cancer but its role remains
controversial. To delineate the cell populations able to respond to Hh ligand stimulation, we …

Objective. To conduct a systematic review of the role that the hedgehog signaling pathway
has in pancreatic cancer tumorigenesis. Method. PubMed search (2000–2010) and …

Abstract Purpose: The Hedgehog (Hh) pathway has emerged as an important pathway in
multiple tumor types and is thought to be dependent on a paracrine signaling mechanism …