Building de novo genome assemblies for complex genomes is possible thanks to long-read
DNA sequencing technologies. However, maximizing the quality of assemblies based on …

Motivation: Next-generation sequencing allows us to sequence reads from a microbial
environment using single-cell sequencing or metagenomic sequencing technologies …

Low-cost short read sequencing technology has revolutionized genomics, though it is only
just becoming practical for the high-quality de novo assembly of a novel large genome. We …

Recent developments in high-throughput sequencing technology have made low-cost
sequencing an attractive approach for many genome analysis tasks. Increasing read …

We describe a new algorithm, meraculous, for whole genome assembly of deep paired-end
short reads, and apply it to the assembly of a dataset of paired 75-bp Illumina reads derived …

Background Assembly algorithm choice should be a deliberate, well-justified decision when
researchers create genome assemblies for eukaryotic organisms from third-generation …

An accurate genome sequence of a desired species is now a pre-requisite for genome
research. An important step in obtaining a high-quality genome sequence is to correctly …

Background Current high-throughput sequencing technologies generate large numbers of
relatively short and error-prone reads, making the de novo assembly problem challenging …

Technologies for next-generation sequencing (NGS) have stimulated an exponential rise in
high-throughput sequencing projects and resulted in the development of new read …

The latest revolution in the DNA sequencing field has been brought about by the
development of automated sequencers that are capable of generating giga base pair data …