Comparative mapping between the human and rodent genomes is one approach for
positional cloning of complex disease loci. The human type 1 diabetes susceptibility locus …

Several genetic insulin-dependent diabetes (Idd) intervals that confer resistance to
autoimmune diabetes have been identified in mice and humans, but the mechanisms by …

Twenty-four named Idd loci that contribute to the development of autoimmune diabetes in
the nonobese diabetic (NOD) mouse have been mapped by linkage and congenic analysis …

The Idd5 locus for autoimmune diabetes in nonobese diabetic (NOD) mice has been
mapped to the proximal half of chromosome 1 and appears to include two loci, Idd5. 1 and …

Abstract Iddm14 (formerly Iddm4) is a non-MHC-linked genetic locus associated with
autoimmune diabetes. Its effects have been well-documented in BB-derived rats in which …

We have previously proposed that sequence variation of the CD101 gene between NOD
and C57BL/6 mice accounts for the protection from type 1 diabetes (T1D) provided by the …

Type 1 diabetes is a multigenic autoimmune disease, the genetic basis for which is perhaps
best characterized in the nonobese diabetic (NOD) mouse model. We previously located a …

Viral antibody–free BBDR and WF rats never develop spontaneous diabetes. BBDR rats,
however, develop autoimmune diabetes after perturbation of the immune system, eg, by viral …

The spontaneous development of autoimmune diabetes in NOD mice suggests that they are
unable to establish and maintain immunologic self-tolerance. Congenic NOD mice …

Type 1 diabetes in the nonobese diabetic (NOD) mouse arises as a consequence of T cell-
mediated destruction of the insulin-producing β cells of the pancreas. Although little is …