[HTML][HTML] Medical gas plasma-stimulated wound healing: Evidence and mechanisms

S Bekeschus, T von Woedtke, S Emmert, A Schmidt - Redox biology, 2021 - Elsevier
Defective wound healing poses a significant burden on patients and healthcare systems. In
recent years, a novel reactive oxygen and nitrogen species (ROS/RNS) based therapy has …

Redox for repair: cold physical plasmas and Nrf2 signaling promoting wound healing

A Schmidt, S Bekeschus - Antioxidants, 2018 - mdpi.com
Chronic wounds and ulcers are major public health threats. Being a substantial burden for
patients and health care systems alike, better understanding of wound pathophysiology and …

[HTML][HTML] Gas plasma-spurred wound healing is accompanied by regulation of focal adhesion, matrix remodeling, and tissue oxygenation

A Schmidt, G Liebelt, F Nießner, T von Woedtke… - Redox biology, 2021 - Elsevier
In response to injury, efficient migration of skin cells to rapidly close the wound and restore
barrier function requires a range of coordinated processes in cell spreading and migration …

Hydrogen peroxide: A central player in physical plasma-induced oxidative stress in human blood cells

S Bekeschus, J Kolata, C Winterbourn… - Free radical …, 2014 - Taylor & Francis
Plasma medicine is an interdisciplinary field and recent clinical studies showed benefits of
topical plasma application to chronic wounds. Whereas most investigations have focused on …

The plasma jet kINPen–A powerful tool for wound healing

S Bekeschus, A Schmidt, KD Weltmann… - Clinical Plasma …, 2016 - Elsevier
The development of cold atmospheric pressure plasma sources was the starting point for the
innovative field of plasma medicine many years ago. Today, a large body of information is …

Gas plasma: medical uses and developments in wound care

G Lloyd, G Friedman, S Jafri, G Schultz… - Plasma Processes …, 2010 - Wiley Online Library
Non‐thermal gas plasmas (NTGPs) are a promising emergent medical technology. a Unlike
thermal plasmas, they generate a complex room temperature mix of reactive species which …

Cold physical plasma modulates p53 and mitogen‐activated protein kinase signaling in keratinocytes

A Schmidt, S Bekeschus, K Jarick… - Oxidative Medicine …, 2019 - Wiley Online Library
Small reactive oxygen and nitrogen species (ROS/RNS) driven signaling plays a significant
role in wound healing processes by controlling cell functionality and wound phase …

Cold atmospheric argon plasma treatment may accelerate wound healing in chronic wounds: Results of an open retrospective randomized controlled study in vivo

G Isbary, W Stolz, T Shimizu, R Monetti, W Bunk… - Clinical Plasma …, 2013 - Elsevier
Previous studies reported a significant reduction in bacterial load in chronic wounds in
patients with cold argon plasma. This open retrospective study evaluated effects on wound …

[HTML][HTML] Nrf2 signaling and inflammation are key events in physical plasma-spurred wound healing

A Schmidt, T von Woedtke, B Vollmar, S Hasse… - Theranostics, 2019 - ncbi.nlm.nih.gov
Wound healing is strongly associated with the presence of a balanced content of reactive
species in which oxygen-dependent, redox-sensitive signaling represents an essential step …

Randomized placebo‐controlled human pilot study of cold atmospheric argon plasma on skin graft donor sites

J Heinlin, JL Zimmermann, F Zeman… - Wound Repair and …, 2013 - Wiley Online Library
Cold atmospheric plasma has already been shown to decrease the bacterial load in chronic
wounds. However, until now it is not yet known if plasma treatment can also improve wound …