The Effects of Delta-9 Tetrahydrocannabinol (THC) on DNA Methylation and MicroRNA Profiles in Bovine Granulosa Cells

S Floccari - 2023 - atrium.lib.uoguelph.ca
This thesis investigates the effects of delta-9-tetrahydrocannabinol (THC) on DNA
methylation and microRNA expression in bovine granulosa cells. With the rise in cannabis …

Cannabis alters epigenetic integrity and endocannabinoid signalling in the human follicular niche

N Fuchs Weizman, BA Wyse, P Szaraz… - Human …, 2021 - academic.oup.com
Abstract STUDY QUESTION Do phytocannabinoids (PCs) affect follicular endocannabinoid
signalling and the epigenome in the surrounding granulosa cells (GCs)? SUMMARY …

CANNABIS SIGNIFICANTLY ALTERS DNA METHYLATION OF THE HUMAN OVARIAN FOLLICLE IN A DOSE-DEPENDENT MANNER

NF Weizman, BA Wyse, J Montbriand, S Jahangiri… - Fertility and …, 2021 - fertstert.org
Objective Cannabis-derived phytocannabinoids are increasingly consumed by women of
childbearing age. The objective of this study was to determine the epigenetic effects of …

DELTA-9-TETRAHYDROCANNABINOL EXPOSURE ALTERS SPERM DNA METHYLATION IN RHESUS MACAQUES

JC Bash, LE Shorey-Kendrick, CB Hanna… - Fertility and …, 2023 - fertstert.org
OBJECTIVE Cannabis is the most commonly used illicit drug by reproductive age males and
emerging evidence suggests it may impact fertility. Our objective was to determine the effect …

The effects of delta-9-tetrahydrocannabinol on mammalian sperm quality, physiology, and transcriptome

V Truong - 2022 - atrium.lib.uoguelph.ca
Cannabis is one of the most widely used recreational drug globally and an estimated 6.1
million Canadians have used cannabis in the past year. The main psychoactive effects of …

O-053 Link between cannabis use and fertility: effects on gamete competence and early embryonic development

L Favetta - Human Reproduction, 2023 - academic.oup.com
Worldwide human fertility has been facing a significant decline over recent years. Therefore,
attention has been focused on identifying environmental and lifestyle risk factors that may be …

THE IMPACT OF THC ON DEVELOPMENTAL PARAMETERS, FERTILIZATION CAPABILITY, EPIGENETIC MODIFICATION IN SPERM AND EMBRYOS PRODUCED …

A Kuzma-Hunt - 2023 - atrium.lib.uoguelph.ca
This thesis explores the impacts of delta-9-tetrhydrocannabinol (THC) on sperm functions
pre-and post-fertilization including the acrosomal reaction, mitochondrial membrane …

Cessation of chronic delta-9-tetrahydrocannabinol use partially reverses impacts on male fertility and the sperm epigenome in rhesus macaques

JC Hedges, CB Hanna, LE Shorey-Kendrick… - Fertility and sterility, 2023 - Elsevier
Objective To determine whether discontinuation of delta-9-tetrahydrocannabinol (THC) use
mitigates THC-associated changes in male reproductive health using a rhesus macaque …

Cannabis significantly alters DNA methylation of the human ovarian follicle in a concentration-dependent manner

N Fuchs Weizman, BA Wyse… - Molecular human …, 2022 - academic.oup.com
Cannabis is increasingly consumed by women of childbearing age, and the reproductive
and epigenetic effects are unknown. The purpose of this study was to evaluate the potential …

Cannabinoid exposure and altered DNA methylation in rat and human sperm

SK Murphy, N Itchon-Ramos, Z Visco, Z Huang… - Epigenetics, 2018 - Taylor & Francis
Little is known about the reproductive effects of paternal cannabis exposure. We evaluated
associations between cannabis or tetrahydrocannabinol (THC) exposure and altered DNA …