Alzheimer's disease (AD) is an incurable chronic neurodegenerative disease. Until now, β-
amyloid, mitochondrial viscosity and the relatively high concentration of hydrogen peroxide …

Abstract Alzheimer's disease (AD), with incurable neurodegenerative damage, has attracted
growing interest in exploration of better AD biomarkers in its early diagnosis. Among various …

Alzheimer's disease is a fatal, incurable, chronic neurodegenerative disease. Diagnosis in
its early and even preclinical stages will be beneficial for its prevention and treatment. In the …

Mitochondria are the most important energy supply centers in the cell, the changes in
function and structure are implicated in many diseases. Among them, Aβ peptide, one of the …

Abnormal accumulation of intracellular and extracellular β-amyloid (Aβ) aggregates is
closely related to the pathogenesis of Alzheimer's disease (AD). In this work, we use …

To enable the early detection and intervention of Alzheimer's disease (AD), it is highly
desirable to develop novel theranostic agents for simultaneous detection of toxic and …

Alzheimer's disease (AD) is a multifaceted neurodegenerative disorder for which the
underlying causes remain largely unknown. Therefore, the development of imaging agents …

Oxidative stress, caused by an imbalance between the production and the accumulation of
reactive oxygen species (ROS), is a prominent cause of the neurotoxicity induced by …

Fibrillar species have been proposed to play an essential role in the cytotoxicity of amyloid
peptide and the pathogenesis of neurodegenerative diseases. Discrimination of Aβ …

It has been speculated that both the intracellular viscosity and H2O2 level in Alzheimer's
disease (AD) brains are higher than that in healthy brains, but direct evidence from living …