Objectives: To provide an appraisal of the evolving paradigms in the pathophysiology of
sepsis and propose the evolution of a new phenotype of critically ill patients, its potential …

Introduction Sepsis is a common, costly and morbid cause of critical illness in trauma and
surgical patients. Ongoing advances in sepsis resuscitation and critical care support …

Clinical and technological advances promoting early hemorrhage control and physiologic
resuscitation as well as early diagnosis and optimal treatment of sepsis have significantly …

Sepsis remains a critical problem with significant morbidity and mortality even in the modern
era of critical care management. Multiple derangements exist in sepsis involving several …

Sepsis represents a dysregulated host response to infection leading to organ dysfunction.
Here, the pathogen triggers an initial exaggerated inflammatory-immune response that …

Dysregulated host immune responses to infection often occur, leading to sepsis, multiple
organ failure, and death. Some patients rapidly recover from sepsis, but many develop …

Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

Sepsis is one of the most common reasons for critically ill patients to be admitted to an
intensive care unit and, despite advances in overall medical care, it represents a major …

Background: Sepsis as a process has been recognized since the time of the Ancient Greeks.
The concept has evolved recently to reflect a disease process of a severe, systemic …

Sepsis is a highly complex and lethal syndrome with highly heterogeneous clinical
manifestations that makes it difficult to detect and treat. It is also one of the major and most …