A key goal for implanted medical devices is that they do not elicit a detrimental immune
response. Macrophages play critical roles in the modulation of the host immune response …

Abstract The Three-dimensional OrbiTrap Secondary Ion Mass Spectrometry (3D OrbiSIMS)
is a secondary ion mass spectrometry instrument, a combination of a Time of Flight (ToF) …

Fibrosis remains a significant cause of failure in implanted biomedical devices and early
absorption of proteins on implant surfaces has been shown to be a key instigating factor …

Implanted medical devices often elicit adverse foreign body responses whereby
macrophages play a central role. Here, we identify simple polymers that instruct different …

The persistent inflammatory host response to an implanted biomaterial, known as the foreign
body reaction, is a significant challenge in the development and implementation of …

Supramolecular polymeric materials are of increasing interest for the use as drug delivery
carriers. A thorough insight in the biocompatibility and the degradation of these materials in …

Understanding the foreign body response (FBR) and desiging strategies to modulate such a
response represent a grand challenge for implant devices and biomaterials. Here, the …

The non-specific host response to implanted biomaterials is often a key challenge of medical
device design. To evaluate biocompatibility, measuring the release of reactive oxygen …

Implants can induce a foreign body reaction that leads to chronic inflammation and fibrosis
in the surrounding tissue. Macrophages help detect the foreign material, play a role in the …

The material-induced foreign body response is a major challenge for implanted medical
devices. This review highlights recent developments in biomimetic approaches to create …