Intratumoral heterogeneity is a major ongoing challenge in the effective therapeutic targeting
of cancer. Accumulating evidence suggests that a fraction of cells within a tumor termed …

In embryonic development and throughout life, there are some cells can exhibit phenotypic
plasticity. Phenotypic plasticity is the ability of cells to differentiate into multiple lineages. In …

The origins of the complex process of intratumoral heterogeneity have been highly debated
and different cellular mechanisms have been hypothesized to account for the diversity within …

Most tumors exhibit intra-tumor heterogeneity, which is associated with disease progression
and an impaired response to therapy. Cancer cell plasticity has been proposed as being an …

Cancer stem cells (CSCs) are self-renewal population localized within cancer niches and
play critical roles in tumor initiation, recurrence and metastasis. Despite extensive research …

The connection between epithelial-mesenchymal (EM) plasticity and cancer stem cell (CSC)
properties has been paradigm-shifting, linking tumor cell invasion and metastasis with …

Abstract Background Cancer stem cells (CSCs) are subpopulations of cancer cells sharing
similar characteristics as normal stem or progenitor cells such as self-renewal ability and …

A small subpopulation of cells within the bulk of tumors share features with somatic stem
cells, in that, they are capable of self-renewal, they differentiate, and are highly resistant to …

Tumor cells actively contribute to constructing their own microenvironment during
tumorigenesis and tumor progression. The tumor microenvironment contains multiple types …

Cancer handles an estimated 7.6 million deaths worldwide per annum. A recent theory
focuses on the role Cancer Stem Cells (CSCs) in driving tumorigenesis and disease …