Cystic Fibrosis (CF) is a lethal autosomal recessive disease caused by mutations in the
gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). The most …

Cystic Fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane
conductance regulator (CFTR) gene. The F508del and G542X are the most common …

Background Genetically engineered animals are essential for gaining a proper
understanding of the disease mechanisms of cystic fibrosis (CF). The rat is a relevant …

The cystic fibrosis (CF) field is the beneficiary of five species of animal models that lack
functional cystic fibrosis transmembrane conductance regulator (CFTR) channel. These …

Animal models of cystic fibrosis (CF) are essential for investigating disease mechanisms and
trialing potential therapeutics. This study generated two CF rat models using clustered …

Nonsense mutations that lead to the insertion of a premature termination codon (PTC) in the
cystic fibrosis transmembrane conductance regulator (CFTR) transcript affect 11% of …

Cystic fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane
conductance regulator (CFTR) gene. The major cause of limited life span in CF patients is …

Cystic fibrosis (CF) is a monogenic recessive genetic disorder caused by mutations in the
CF Transmembrane-conductance Regulator gene (CFTR). Remarkable progress in basic …

Recent discoveries and technical advances in genetic engineering, methods called gene or
genome editing, provide hope for repairing genes that cause diseases like cystic fibrosis …

Cystic fibrosis (CF) is a severe genetic disease for which curative treatment is still lacking.
Next generation biotechnologies and more efficient cell-based and in vivo disease models …