HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function
V Appay, DF Nixon, SM Donahoe… - The Journal of …, 2000 - rupress.org
The use of peptide–human histocompatibility leukocyte antigen (HLA) class I tetrameric
complexes to identify antigen-specific CD8+ T cells has provided a major development in …
complexes to identify antigen-specific CD8+ T cells has provided a major development in …
Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic
D Zhang, P Shankar, Z Xu, B Harnisch… - Blood, The Journal …, 2003 - ashpublications.org
Despite the frequency of HIV-specific CD8 T cells, most HIV-infected patients do not control
viral replication without antiviral drugs. Although CD8 T cells are important in containing …
viral replication without antiviral drugs. Although CD8 T cells are important in containing …
Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children
PJR Goulder, Y Tang, C Brander, MR Betts… - The Journal of …, 2000 - rupress.org
The highly sensitive quantitation of virus-specific CD8+ T cells using major histocompatibility
complex–peptide tetramer assays has revealed higher levels of cytotoxic T lymphocytes …
complex–peptide tetramer assays has revealed higher levels of cytotoxic T lymphocytes …
CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection
G Chen, P Shankar, C Lange, H Valdez… - Blood, The Journal …, 2001 - ashpublications.org
CD8 T cells are classified as naı̈ve, effector, or memory cells on the basis of CD45RA,
CD62L, and CCR7 expression. Sequential engagement of cell-surface CD62L and CCR7 …
CD62L, and CCR7 expression. Sequential engagement of cell-surface CD62L and CCR7 …
Beyond Help: Direct Effector Functions of Human Immunodeficiency Virus Type 1-Specific CD4+ T Cells
The immune correlates of protection in human immunodeficiency virus type 1 (HIV-1)
infection remain poorly defined, particularly the contribution of CD4+ T cells. Here we …
infection remain poorly defined, particularly the contribution of CD4+ T cells. Here we …
HIV-1–specific cytotoxicity is preferentially mediated by a subset of CD8+ T cells producing both interferon-γ and tumor necrosis factor–α
M Lichterfeld, XUG Yu, MT Waring, SK Mui… - Blood, 2004 - ashpublications.org
CD8+ T cells play a crucial role in the control of viral infections by direct elimination of
infected cells and secretion of a number of soluble factors. Recent data suggest that HIV-1 …
infected cells and secretion of a number of soluble factors. Recent data suggest that HIV-1 …
Loss of HIV-1–specific CD8+ T Cell Proliferation after Acute HIV-1 Infection and Restoration by Vaccine-induced HIV-1–specific CD4+ T Cells
M Lichterfeld, DE Kaufmann, XG Yu, SK Mui… - The Journal of …, 2004 - rupress.org
Virus-specific CD8+ T cells are associated with declining viremia in acute human
immunodeficiency virus (HIV) 1 infection, but do not correlate with control of viremia in …
immunodeficiency virus (HIV) 1 infection, but do not correlate with control of viremia in …
Cooperativity of HIV-specific cytolytic CD4 T cells and CD8 T cells in control of HIV viremia
S Johnson, M Eller, JE Teigler, SM Maloveste… - Journal of …, 2015 - Am Soc Microbiol
ABSTRACT CD4+ T cells play a pivotal role in the control of chronic viral infections.
Recently, nontraditional CD4+ T cell functions beyond helper effects have been described …
Recently, nontraditional CD4+ T cell functions beyond helper effects have been described …
Preferential infection and depletion of Mycobacterium tuberculosis–specific CD4 T cells after HIV-1 infection
C Geldmacher, N Ngwenyama, A Schuetz… - Journal of Experimental …, 2010 - rupress.org
HIV-1 infection results in the progressive loss of CD4 T cells. In this study, we address how
different pathogen-specific CD4 T cells are affected by HIV infection and the cellular …
different pathogen-specific CD4 T cells are affected by HIV infection and the cellular …
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors
SA Migueles, AC Laborico, WL Shupert… - Nature …, 2002 - nature.com
It is unclear why immunological control of HIV replication is incomplete in most infected
individuals. We examined here the CD8+ T cell response to HIV-infected CD4+ T cells in …
individuals. We examined here the CD8+ T cell response to HIV-infected CD4+ T cells in …