Rho guanosine triphosphatases (GTPases) are key regulators in a number of cellular
functions, including actin cytoskeleton remodeling and vesicle traffic. Traditionally, Rho …

Rho guanosine triphosphate hydrolases (GTPases) are molecular switches that cycle
between an inactive guanosine diphosphate (GDP)-bound and an active guanosine …

Dysregulation of glucose homeostasis leading to metabolic syndrome and type 2 diabetes is
the cause of an increasing world health crisis. New intriguing roles have emerged for Rho …

Insulin is secreted into blood vessels from β cells of pancreatic islets in response to high
blood glucose levels. Insulin stimulates an array of physiological responses in target tissues …

Insulin is a hormone that regulates the blood glucose level by stimulating various
physiological responses in its target tissues. In skeletal muscle and adipose tissue, insulin …

The molecular events governing skeletal muscle glucose uptake have pharmacological
potential for managing insulin resistance in conditions such as obesity, diabetes, and …

The Rho family of small GTPases orchestrates fundamental biological processes such as
cell cycle progression, cell migration, and actin cytoskeleton dynamics, and their aberrant …

Several small guanosine triphosphatases (GTPases) from the Ras protein superfamily
regulate glucose-stimulated insulin secretion in the pancreatic islet β-cell. The Rho family …

Cells and tissues are continuously exposed to both chemical and physical stimuli and
dynamically adapt and respond to this variety of external cues to ensure cellular …

Extant studies have implicated the Rho subfamily of guanosine triphosphate–binding
proteins (G-proteins; eg, Rac1) in physiological insulin secretion from isolated β-cells …