CIViC is an expert-crowdsourced knowledgebase for Clinical Interpretation of Variants in
Cancer describing the therapeutic, prognostic, diagnostic and predisposing relevance of …

Abstract CIViC (Clinical Interpretation of Variants in Cancer; civicdb. org) is a crowd-sourced,
public domain knowledgebase composed of literature-derived evidence characterizing the …

Precision oncology relies on accurate discovery and interpretation of genomic variants,
enabling individualized diagnosis, prognosis and therapy selection. We found that six …

Purpose Several professional societies have published guidelines for the clinical
interpretation of somatic variants, which specifically address diagnostic, prognostic, and …

Large-scale cancer genomics discovery projects such as The Cancer Genome Atlas (TCGA)
and the International Cancer Genome Consortium (ICGC) have systematically characterized …

Early data-sharing efforts have led to improved variant interpretation and development of
treatments for rare diseases and some cancer types (–). However, such benefits will only be …

Of hundreds to thousands of somatic mutations that exist in each cancer genome, a large
number are unique and non-recurrent variants. Prioritizing genetic variants identified via …

Accurate and consistent variant classification is required for Precision Medicine. But clinical
variant classification remains in its infancy. While recent guidelines put forth jointly by the …

The scale of tumor genomic profiling is rapidly outpacing human cognitive capacity to make
clinical decisions without the aid of tools. New frameworks are needed to help researchers …

Abstract The International Cancer Genome Consortium (ICGC) aims to catalog genomic
abnormalities in tumors from 50 different cancer types. Genome sequencing reveals …