Covering: 1995 to 2010 Here, we review studies that have investigated the activity of plant-
derived compounds against Trypanosoma cruzi, the etiologic agent of Chagas' disease. In …

Background Chagas disease, caused by the protozoan Trypanosoma cruzi, is a neglected
disease that affects~ 7 million people worldwide. Development of new drugs to treat the …

Protozoan tropical diseases cause great suffering throughout developing countries, with
high rates of morbidity and mortality. American Trypanosomiasis affects 16-18 million people …

Chagas disease, caused by Trypanosoma cruzi, is treated with only two drugs;
benznidazole and nifurtimox. These drugs have some disadvantages, including their …

Parasitic diseases are widespread in less developed countries, and are a major cause of
suffering and inability of the affected populations to improve their own living conditions …

Background: Chagas disease (American Trypanosomiasis) is classified by the World Health
Organization (WHO) as one of the seventeen neglected tropical diseases (NTD), affecting …

Chagas disease and sleeping sickness are neglected tropical diseases closely related to
poverty, for which the development of plant-derived treatments has not been a promising …

Chagas' disease is responsible for significant mortality and morbidity in Latin America.
Current treatments display variable efficacy and have adverse side effects, hence more …

Secondary metabolites obtained from natural sources are medicinally relevant molecules.
About one-third of all FDA-approved drugs are derived from or based on natural products …

Six plant-derived simple β-carboline alkaloids and eight other plant derivatives were tested
for activity against the protozoan parasite, Trypanosoma cruzi, the organism responsible for …