[HTML][HTML] Small patient datasets reveal genetic drivers of non-small cell lung cancer subtypes using machine learning for hypothesis generation

M Cook, B Qorri, A Baskar, J Ziauddin… - Exploration of …, 2023 - explorationpub.com
Aim: Many small datasets of significant value exist in the medical space that are being
underutilized. Due to the heterogeneity of complex disorders found in oncology, systems …

Small patient datasets reveal genetic drivers of non-small cell lung cancer subtypes using a novel machine learning approach

C Moses, Q Bessi, B Amruth, Z Jalal, P Luca… - medRxiv, 2021 - medrxiv.org
Background There are many small datasets of significant value in the medical space that are
being underutilized. Due to the heterogeneity of complex disorders found in oncology …

Identification of Gene Biomarkers for Distinguishing Small‐Cell Lung Cancer from Non‐Small‐Cell Lung Cancer Using a Network‐Based Approach

F Long, JH Su, B Liang, LL Su… - BioMed research …, 2015 - Wiley Online Library
Lung cancer consists of two main subtypes: small‐cell lung cancer (SCLC) and non‐small‐
cell lung cancer (NSCLC) that are classified according to their physiological phenotypes. In …

Prediction uncertainty estimates elucidate the limitation of current NSCLC subtype classification in representing mutational heterogeneity

A Puiu, C Gómez Tapia, MER Weiss, V Singh… - Scientific Reports, 2024 - nature.com
The heterogeneous pathogenesis and treatment response of non-small cell lung cancer
(NSCLC) has led clinical treatment decisions to be guided by NSCLC subtypes, with lung …

An interpretable approach for lung cancer prediction and subtype classification using gene expression

B Ramos, T Pereira, J Moranguinho… - 2021 43rd Annual …, 2021 - ieeexplore.ieee.org
Lung cancer is the deadliest form of cancer, accounting for 20% of total cancer deaths. It
represents a group of histologically and molecularly heterogeneous diseases even within …

[HTML][HTML] Gene expression signature differentiates histology but not progression status of early-stage NSCLC

R Charkiewicz, J Niklinski, J Claesen, A Sulewska… - Translational …, 2017 - Elsevier
Advances in molecular analyses based on high-throughput technologies can contribute to a
more accurate classification of non–small cell lung cancer (NSCLC), as well as a better …

Pipeline design to identify key features and classify the chemotherapy response on lung cancer patients using large-scale genetic data

MG Valdés, I Galván-Femenía, VR Ripoll, X Duran… - BMC systems …, 2018 - Springer
Background During the last decade, the interest to apply machine learning algorithms to
genomic data has increased in many bioinformatics applications. Analyzing this type of data …

An explainable AI-driven biomarker discovery framework for Non-Small Cell Lung Cancer classification

K Dwivedi, A Rajpal, S Rajpal, M Agarwal… - Computers in Biology …, 2023 - Elsevier
Abstract Non-Small Cell Lung Cancer (NSCLC) exhibits intrinsic heterogeneity at the
molecular level that aids in distinguishing between its two prominent subtypes—Lung …

Six-Gene Signature for Differential Diagnosis and Therapeutic Decisions in Non-Small-Cell Lung Cancer—A Validation Study

R Charkiewicz, A Sulewska, P Karabowicz… - International Journal of …, 2024 - mdpi.com
Non-small-cell lung cancer (NSCLC) poses a challenge due to its heterogeneity,
necessitating precise histopathological subtyping and prognostication for optimal treatment …

Functional effects of four or fewer critical genes linked to lung cancers and new subtypes detected by a new machine learning classifier

Z Zhang - bioRxiv, 2021 - biorxiv.org
Finding genes biologically directly or indirectly related to lung cancer has been drawing
much attention, and many genes directly related to lung cancer have been reported …